Synthesis, in vitro and in silico studies of indolequinone derivatives against clinically relevant bacterial pathogens.

CONCLUSION: The highly substituted indolequinones were obtained in moderate to good yields. The pharmacological study indicated that these compounds should be exploited in the search for a leading substance in a project aimed at obtaining new antimicrobials effective against Gram- negative bacteria.
PMID: 31868148 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - December 21, 2019 Category: Chemistry Authors: Leite TOC, Novais JS, de Carvalho BLC, Ferreira VF, Miceli LA, Fraga L, Abrahim-Vieira B, Rodrigues CR, Sá Figueiredo AM, Castro HC, Cunha AC Tags: Curr Top Med Chem Source Type: research