Long-term use of systemic azole antifungals can result in hepatotoxicity and other serious adverse effects

AbstractLong-term use of systemic azole antifungals (i.e. fluconazole, isavuconazole, itraconazole, ketoconazole, posaconazole and voriconazole) can result in serious adverse drug effects (ADEs), such as hepatotoxicity and cardiac effects. Cytochrome P450 inhibition by azoles contributes to many ADEs, such as adrenal insufficiency due to hormone disruption, while pharmacokinetic interactions can lead to myositis or peripheral neuropathy. Other notable ADEs include pancreatitis, bone pain, renal failure, skin cancer and Stevens-Johnsons syndrome. ADEs may be managed with monitoring, adjusting dosages and switching azoles.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research