MicroRNAs and Child Neuropsychiatric Disorders: A Brief Review.

MicroRNAs and Child Neuropsychiatric Disorders: A Brief Review. Neurochem Res. 2019 Nov 26;: Authors: Paul S, Reyes PR, Garza BS, Sharma A Abstract MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that regulate gene expression through posttranscriptional mechanisms via degradation or inhibition of specific mRNAs targets. In recent years, abundant studies have illustrated the relevance of miRNAs in human psychopathology. In this current review, neuropsychiatric disorders with moderate to high prevalence among children and adolescents such as Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, Dyslexia, Epilepsy, Schizophrenia and Tourette Syndrome were discussed focusing on the functional consequence of altered miRNA expression during the development of such diseases. The insight about the roles that miRNAs play in central nervous systems development such as cell proliferation and differentiation, synaptogenesis, synaptic plasticity, and apoptosis might be the key to explicate novel biomarkers for diagnosis and prognosis of these disorders, as well as the finding of new targets for drug development for therapeutic approaches. PMID: 31773374 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

Related Links:

Conclusions The results suggest that the proposed end-to-end deep learning architecture achieves better performance as compared to the other state-of-the-art methods. The findings suggest that the frontal lobe contains the most discriminative power towards the classification of ADHD.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Authors: Ceskova E Abstract Introduction: Depressive symptoms may occur in any phase of schizophrenia and can have far-reaching consequences.Areas covered: The author focuses on recent reviews and meta-analyses dealing with the prevalence, importance, etiopathogenesis, and pharmacotherapy of comorbid depression and schizophrenia. Depressive symptoms in acute episodes may improve in parallel with psychosis due to antipsychotic treatment. Therefore, the first step is to evaluate the current antipsychotic treatment of psychotic symptoms and consider changing the dosage. A second step is switching antipsychotic medicat...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
AbstractAutism is more commonly diagnosed in males than females. One explanation is the ‘female protective effect’: there is something inherent in being female which reduces the likelihood of developing autism. However, evidence suggests that the condition is underdiagnosed in females, perhaps because females express their autism in ways which do not meet current diagnostic criteri a. This review explores evidence for a female-typical autism presentation, the Female Autism Phenotype (FAP) and the component of camouflaging (compensating for and masking autistic characteristics) in particular. The evidence so far...
Source: Review Journal of Autism and Developmental Disorders - Category: Child Development Source Type: research
Alongside positive and negative symptomatology, deficits in working memory, attention, selective learning processes, and executive function have been widely documented in schizophrenia spectrum psychosis. These cognitive abnormalities are strongly associated with impairment across multiple function domains and are generally treatment-resistant. The DTNBP1 (dystrobrevin-binding protein-1) gene, encoding dysbindin, is considered a risk factor for schizophrenia and is associated with variation in cognitive function in both clinical and nonclinical samples. Downregulation of DTNBP1 expression in dorsolateral prefrontal cortex ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Early intervention for symptoms associated with autism spectrum disorder is critical for helping families improve outcomes for their children, according to updated recommendations from the American Academy of Pediatrics.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
The agency said that constipation, a common side effect of the popular schizophrenia medication, could progress to serious bowel complications, including complete bowel blockage, if not treated.News Alerts
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Alert Source Type: news
If replicated in future trials, the drug treatment might be a breakthrough, since current treatments for autism in preschool kids are mainly behavioral -- therapies such as using play and activities with parents to improve a child's language, social and thinking skills.
Source: WebMD Health - Category: Consumer Health News Source Type: news
This study mainly explored the antidepressant-like effects and mechanisms of protoilludane sesquiterpenoid aromatic esters from Armillaria mellea (PSAM) in depressive mice induced by chronic unpredictable mild stress (CUMS). The results demonstrated that PSAM exerted antidepressant-like effects in mice, as indicated by reversing CUMS-induced changes in body weight gain, sucrose preference, and behavior in the open field test, elevated plus maze test, tail suspension test and forced swimming test. Meanwhile, PSAM inhibited the release of hippocampus IL-6, IL-1β and TNF-α levels, and down-regulated hippocampus cas...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
The average life expectancy of people with schizophrenia is 10 to 20 years less than in the general population. There has long been concern that one reason is long-term use of antipsychotic drugs to ease symptoms such as delusions and hallucinations.
Source: WebMD Health - Category: Consumer Health News Source Type: news
ConclusionTo the best of our knowledge, this is the first review dedicated to the characteristics of paediatric patients with PRS and epilepsy. Seizures are usually focal, became refractory in 40%, and have a significant impact on the quality of life and neurodevelopment of patients.
Source: Seizure - Category: Neurology Source Type: research
More News: ADHD | Autism | Brain | Child Development | Children | Dyslexia | Epilepsy | Genetics | Hyperactivity | Neurology | Neuroscience | Schizophrenia | Study | Tourette Syndrome