High glucose concentrations mask cellular phenotypes in a stem cell model of tuberous sclerosis complex

This article is part of the Special Issue “Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Publication date: Available online 25 January 2020Source: Stem Cell ResearchAuthor(s): YI Yan, Yinghui Qiu, Aonan Zhao, Jian Zhao, Ying Wang, Yulei DengAbstractA 66-year old mild cognitive impairment (MCI) female patient donated her Peripheral blood mononuclear cells (PBMC). PBMC was reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, KLF4, SOX2 and C-MYC. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry and ability of differentiation spontaneously into 3 germ layers in vitro. Moreover, the iPSC line displayed a normal karyotype. The apolipoprotein E (...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Zhao J, Mu L, Wang Z, Fang X, He X, Zhang X, Xu X Abstract Circular RNAs (circRNAs) are categorized as non‑coding RNAs that, unlike widely known canonical linear RNAs, form a covalently closed continuous loop without 5' or 3' polarities, which enables them to resist digestion by RNA exonucleases. Although the functions of circRNAs remain largely unknown, accumulated evidence has demonstrated that circRNAs can act as microRNA sponges, which allows them to regulate numerous biological processes and disease mechanisms, including apoptosis, angiogenesis, invasion, metastasis and stem cell differentiation. Al...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Li S, Wang M, Zhou J Abstract Biobanking plays an important role between clinical practice and translational research. In addition to the traditional biomolecular-based biobanks, there is a growing interest in establishing living biobanks, including organoid biobanks that can collect and store viable and functional tissues and proliferative cell types for long periods of time. An organoid is a three-dimensional cell complex derived by self-organization of small tissue blocks or stem cells, which can recapitulate the phenotypic and genetic characteristics of targeted human organs. Publications on brain orga...
Source: Biopreservation and Biobanking - Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
In this study, we review the recent studies that explore CRISPR potency in gene engineering of MSCs, which have great relevance in MSC-based therapies. However, CRISPR/Cas technology make possible specific targeting of loci in target genes, but next-generation MSC-based therapies to achieve extensive clinical application need dedicated efforts. PMID: 31974923 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Norepinephrine from the sympathetic nervous system depletes stem cells responsible for hair color
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
In conclusion, PLGA NPs can efficiently carry their payloads to glioma tissue and the combined use of anticancer and anti-inflammatory drugs may exert additional anti-tumor activity.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
As researchers confirm that stress can turn you grey, we look at the other scientific factors that could salt-and-pepper your crowning gloryThis week, scientists from Harvard demonstrated that stress canaccelerate the greying of human hair. The researchers found that stress prompts the production of a hormone that affects the melanocyte cells involved in making hair pigments. The scientists hope that this discovery will add to the understanding of how the depletion of stem cells contributes to ageing in general.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Ageing Genetics Biology Science Health Society Source Type: news
This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31761686 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Conclusions: L-1-[18F]FETrp showed clear retention in medulloblastoma tumors of Smo-Smo mice. Our preliminary medulloblastoma tumor tissue analysis indicates high expression of TDO2 enzyme, which suggests the tracer uptake reflects TDO2-mediated KP. These preclinical studies suggest that TDO2 may be a therapeutic target for medulloblastoma and L-1-[18F]FETrp has potential for PET imaging of medulloblastoma.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
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