Featured Neuropathologist: Eddie Lee, MD, PhD

Edward B. Lee, MD, PhDFrom time to time on Neuropathology Blog, we profile a prominent neuropathologist. In the past, we ' ve featured the likes of Craig Horbinski, Roger McLendon,Jan Leestma,Karra Jones,Areli Cuevas-Ocampo,Michael Punsoni,andPJ Cimino, among others. Today we feature Eddie Lee, MD, PhD. Dr. Lee is an assistant professor in the pathology department at the University of Pennsylvania. Here ' s a Q&A with the illustrious Dr. Lee:1. Why did you decide to become a neuropathologist?The three major topics that dominate Alzheimer ’s disease research are amyloid, tau, and neuroinflammation.  The discovery of genetic mutations that cause AD or related dementias, and more recent GWAS studies support the idea that these three are perhaps the most important factors that drive AD pathophysiology.  However, it is sometimes forgotten that these were first and foremost neuropathologic observations discovered by studying human tissues using histology and/or biochemistry by George Glenner and the McGeers.  Genetics came later and was made possible by the neuropathology.  The same can be said regarding TDP-43.  This taught me that neuropathology can be a rock solid foundation for building a research career.  I have always been drawn to basic biomedical research but think that clinical training provides a sort of “compass” by which you can guide your research program.  To this day, the foundation of my research is ne...
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs