Dietary Phosphate Restriction Attenuates Polycystic Kidney Disease in Mice.

Dietary Phosphate Restriction Attenuates Polycystic Kidney Disease in Mice. Am J Physiol Renal Physiol. 2019 Nov 04;: Authors: Omede F, Zhang S, Johnson C, Daniel E, Zhang Y, Fields TA, Boulanger J, Liu S, Ahmed I, Umar S, Wallace DP, Stubbs JR Abstract Studies in rodents with reduced nephron mass suggest a strong positive correlation between dietary phosphate consumption and CKD progression. Prior work by our group demonstrated dietary phosphate restriction can prevent tubular injury and microcyst formation in rodents with glomerulonephritis. Tubular injury and cystic dilation of tubules are key contributors to kidney function decline in polycystic kidney disease (PKD). Here, we determined if dietary phosphate restriction slows renal cyst growth and fibrosis in a mouse model of PKD. Pcy/pcy mice received a normal phosphate (0.54%) or a phosphate-restricted (0.02%) diet (n=10/group) from 7 to 20 weeks of age. All other major dietary constituents, including protein content, were comparable between diets. At 20 weeks, body weight, kidney weight to body weight ratio (KW/BW), cyst burden, and kidney fibrosis were quantified. Pcy/pcy mice fed a phosphate-restricted diet had lower serum phosphate, fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH), along with elevated serum calcium and increased kidney Klotho gene expression compared to mice consuming the control diet. Dietary phosphate restriction resulted in a 25% lower KW...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research