Evacuating the Nefarious Subungual Hematomas
Subungual hematomas can be a terror. They are painful, ugly-looking, nefarious, and sometimes confusing. The ultimate goal is to drain the accumulated blood and relieve the painful pressure.The best intervention is easy and straightforward: Leave the nail in place, and evacuate the blood under it. (Hand Surg. 2012;17:151; Am J Emerg Med. 2006;24:875; Emerg Med J. 2003;20:65, http://bit.ly/2mHV1cO.) Then, provide excellent discharge information without prescribing antibiotics.A subungual hematoma in a 21-year-old man who slammed his thumb in a car door about 12 hours before ED arrival. Photo by M. Roberts.Distal extremities have millions of nerve endings, and preservation of the tissue and bone is crucial. Clinicians should test circulation and motor and sensation of the digit. Blood under a fingernail or toenail is usually caused by direct trauma such as crush injury or a stubbed toe to the distal phalanx.The accumulation of blood causes the nail to discolor (to black, blue, or purple). The blood comes from a laceration to the nail bed or a tuft fracture. A significant collection of blood around the paronychium may be a clue that the patient has an avulsed nail and that removal of the nail may be indicated. It is important to treat all types of injuries within 48 hours of injury. (StatPearls Publishing. May 18, 2019; http://bit.ly/2ndcZDO; Roberts and Hedges' Clinical Procedures in Emergency Medicine, 7th Edition. Philadelphia: Elsevier; 2018, p. 744-756.) AP...
Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis. PMID: 32233877 [PubMed - as supplied by publisher]
Authors: Sumida Y, Yoneda M, Ogawa Y, Yoneda M, Okanoue T, Nakajima A Abstract Introduction: There is an unmet medical need for an effective anti-fibrotic treatment for NASH with advanced fibrosis.Areas covered: The authors review the current and novel agents for the treatment of NASH with fibrosis. They also consider the potential future strategies of combination therapies.Expert opinion: Farnesoid X receptor (FXR) agonist (obeticholic acid [OCA]) significantly ameliorated hepatic fibrosis in NASH stage 2/3 fibrosis in an interim analysis of phase 3 trial. Because OCA has several drawbacks such as itching and elev...
One of the biggest challenges of this unsettling time is the isolation we feel as we’re separated from friends and family, all the people for whom we care most deeply. But just being alone is only part of the difficulty. Our sense of remoteness is intensified by a pall of unease we can’t define: Loss and sorrow are also in the air. We fear losing—or we may have already lost—people we love. And when we work up the courage to look beyond our individual personal spheres, we see that many people who have made our world better, in big and small ways, have vanished before we were ready to let them go. But...
Publication date: Available online 2 April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Samit Ghosal, Sumit Sengupta, Milan Majumder, Binayak Sinha
PMID: 32238125 [PubMed - as supplied by publisher]
Publication date: Available online 3 April 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yangang Cheng, Yan Liu, Jinyan Tan, Yanping Sun, Wei Guan, Peng Jiang, Bingyou Yang, Haixue Kuang
PMID: 32237117 [PubMed - in process]
Demand has exploded for rubbing alcohol and alcohol swabs, used as disinfectants against the coronavirus. People with diabetes who rely on the products for infection control have been left scrambling.Kaiser Health News
Abstract Ayurveda oil contains numerous source of biological constituents which plays an important role in reducing the pain relief caused during bone fracture. The aim of the study is to fabricate the polyurethane (PU) scaffold for bone tissue engineering added with ayurveda amla oil using electrospinning technique. Scanning Electron Microscopy (SEM) analysis showed that the fabricated nanocomposites showed reduced fiber diameter (758 ± 185.46 nm) than the pristine PU (890 ± 116.91 nm). Fourier Infrared Analysis (FTIR) revealed the existence of amla oil in the PU matrix by hydrogen bond formation. T...
Some Americans, fearing food shortages from COVID-19, have cleaned out supermarket shelves. Yet there's too much food in some places. Farmers are dumping milk and vegetables that they can't sell.(Image credit: Nati Harnik/AP)
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