Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer.

In conclusion, HF-CDAA feeding in C57Bl/6J mice was identified as an optimal model of steatohepatitis with robust fibrosis and ductular proliferations that progress to cirrhosis and HCC within 24 weeks. This model will aid the testing of interventions and drugs for severe NASH. PMID: 31630534 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31630534?dopt=Abstract

Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 20, 2019 Category: Physiology Authors: Wei G, An P, Vaid K, Nasser I, Huang P, Tan L, Zhao S, Schuppan D, Popov Y Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research