Risk factors for venous thromboembolism in individuals undergoing coronary artery bypass grafting
ConclusionsThe overall VTE rate after CABG has been low. However, the condition has been associated with worse 30-day postoperative outcomes and complications. The independent predictors of VTE development included a history of bleeding disorders, congestive heart failure in the 30 days before surgery, and operative time of ≥310 minutes. Understanding these risk factors should aid physicians in the decisions regarding prophylaxis and treatment.
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Qiujin Jia, Lirong Wang, Xiaonan Zhang, Yuejia Ding, Hao Li, Yingxi Yang, Ao Zhang, Yanyang Li, Shichao Lv, Junping ZhangAbstractIn recent years, although the concept and means of modern treatment of chronic heart failure(CHF) are continually improving, the readmission rate and mortality rate are still high. At present, there is evidence that there is a link between gut microbiota and heart failure, so the intervention of gut microbiota and its metabolites is expected to become a potential new therapeutic target in heart failure. ...
ConclusionThis study suggests that the post-auricular approach is a feasible and less time consuming route for round window drug delivery experiments in Wistar albino rats. Recognition of anatomical landmarks, particularly the facial nerve is the key to surgery.
Authors: Krassas GE, Markou KB Abstract The aim of this review is to provide relevant information regarding the impact of thyroid disease, starting from birth and mainly concerning hyperthyroidism and hypothyroidism, on reproduction. Hyperthyroidism occurs much less commonly in children than hypothyroidism, with Graves' disease (GD) being the most common cause of thyrotoxicosis in children. Children born with neonatal GD have no defects in the reproductive system that could be related to hyperthyroidism. Current treatment options include antithyroid drugs (ATD), surgery, and radioactive iodine (RAI). In males, norm...
This article reviews the common complications of cardiothoracic surgery focusing on the role of imaging and clues to diagnosis. PMID: 31731897 [PubMed - in process]
CONCLUSIONS Vitrectomy for endophthalmitis due to open ocular trauma performed within five days of injury restored visual acuity. EAV was shown to be an effective alternative to CV. PMID: 31732711 [PubMed - in process]
Should we look for silent pulmonary embolism in patients with deep venous thrombosis? Anybody else find themselves scanning your DVT patients for PE more frequently after the publishing of all this literature touting the high percentage of silent PEs with concomitant DVTs? Some of these numbers are crazy. 32%-66% in some of these studies. I doubt the clinical relevance. Most of these pt's are asymptomatic from the PE and are on proper anti-coagulation for the DVT and would probably be fine... Silent PE
Anyone have any good stories?
A new look at an old study helps clarify some of the mystery on the safe use of digoxin in heart failure.European Heart Journal
Rare bleeding disorders usually begin in childhood and manifest as varying degrees of bleeding, which can be life-threatening in severe cases. With the development of gene editing technology, it is expected that hereditary coagulation factor disorders will someday be fundamentally cured by gene therapy. On account of their rarity, comprehension of these diseases is essential for the application of new treatment strategies. We have compiled the features of some newly discovered mutations of prothrombin, factor VII, and factor X in recent years. In addition, this review introduces the advances and obstacles in gene therapy.
This study's results suggest that both combination and sequential therapy of pd-FVIIa/FX and other bypassing agents are well tolerated and effective for the control of perioperative bleeding in haemophilia patients with high-responding inhibitors.
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