Cancers, Vol. 11, Pages 1465: Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy
Cancers, Vol. 11, Pages 1465: Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy
Cancers doi: 10.3390/cancers11101465
Authors:
Francesca Cuomo
Lucia Altucci
Gilda Cobellis
Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.
Source: Cancers - Category: Cancer & Oncology Authors: Francesca Cuomo Lucia Altucci Gilda Cobellis Tags: Review Source Type: research
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