Severe malaria in pregnant women hospitalized between 2010 and 2014 in the Department of Antioquia (Colombia)
Conclusions: Severe malaria is a highly frequent event in pregnant women, without differences by Plasmodium species. It shows early recognizable dangers signs. Hospital under-reporting was identified in 88% of severe cases as well as a lack of laboratory tests for a more comprehensive diagnosis. A protocol for the clinical diagnosis of pregnant women with malaria is required. PMID: 31529822 [PubMed - in process]
CONCLUSIONS: In patients requiring surgery during vvECMO therapy with perioperative transfusion of two or more PRBCs preoperative fibrinogen levels were significantly reduced compared to patients with transfusion of less than two PRBCs. No other analyzed lab value showed any predictive qualities in terms of bleeding. PMID: 31630509 [PubMed - as supplied by publisher]
CONCLUSIONS: Perioperative, i.v. lidocaine administration influences postoperative serum concentrations of endocannabinoids and NAEs in children. PMID: 31630508 [PubMed - as supplied by publisher]
This article compares the two devices to provide guidance on the selection and use of these monitoring systems. Their second-generation assays, TEG 6S and ROTEM Sigma, are also discussed. PMID: 31630507 [PubMed - as supplied by publisher]
CLINICS IN PERINATOLOGY
Conclusion: The presentation of PPCRA has been sporadic in the majority of cases. Inflammatory and hereditary origins have been anecdotally cited. Our young patient showed concurrent presentation of inflammatory and hereditary origin of PPCRA. We suggest that a careful investigation of systemic inflammation should be done in children with suggestive extraocular symptoms in the setting of PPCRA. PMID: 31631731 [PubMed - as supplied by publisher]
Authors: special issue: “Focus on pediatric nephrology”, Chimenz R, Cannavò L, Viola V, Di Benedetto V, Scuderi MG, Pensabene L, Salvo V, D'Angelo G, Stroscio G, Impollonia D, Concolino D, Fede C, Alibrandi A, Cuppari C Abstract Urolithiasis is a well-known condition that can affect any part of the urinary tract. With a rate of 3-5% the incidence of upper urinary tract for long has been higher in adults (1-3), but recently it has increased among children reaching 3,3% . Indeed, more than 1% of all urinary stones are seen in patients aged less than 18 years (4). Pediatric urolithiasis is endemic i...
Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondral progenitor expansion during mammalian skeletal development. Aside from pain sensation, little is known regarding the role of sensory innervation in bone repair. Here, we characterized the reinnervation of tissue following experimental ulnar stress fracture and assessed the impact of loss of TrkA signaling in this process. Sequential histological data obtained in reporter mice subjected to fracture demonstrated a marked ...
Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for therapeutic development. Cell-free hemoglobin that is released from erythrocytes into the cerebrospinal fluid (CSF) is suggested to cause vasoconstriction and neuronal toxicity, and correlates with the occurrence of DIND. Cell-free hemoglobin in the CSF of patients with aSAH disrupted dilatory NO signaling ex vivo in cerebral arteries, which shifted vascular tone balance from dilation to constriction. We found that selective removal of hemoglobin from pati...
CONCLUSIONS: The results highlighted the limited use of clinical coordination mechanisms in both public healthcare networks studied here, with problems in their use. Changes are required that affect directly organisational factors (time for coordination and working conditions) and professional factors (attitudes towards collaborative work). PMID: 31630926 [PubMed - as supplied by publisher]
A 63-year-old woman initially presented to a local urologist with a 9-month history of hematuria/vaginal bleeding followed by urinary retention. Computed tomographic imaging demonstrated a markedly distended urinary bladder with moderate bilateral hydronephrosis. Cystoscopy revealed no evidence of bladder tumor or urethral abnormality, and recurrent urinary tract infection was suspected. The patient developed worsened vaginal bleeding over a 6-month period, and anterior vaginal fullness was then appreciated on examination; she required a permanent indwelling catheter.