In vitro study for stimulation effect of human bone marrow mesenchymal stem cell secretome on humen granulosa cell

Primary ovarian insufficiency (POI) refers to ovarian loss of function under the age of 40 years and lead those patients to usually present by amenorrhea and infertility. One of the reasons of POI is chemotherapy for cancer patients. It is broadly believed that chemotherapy drugs may vastly eliminate granulosa cells which are essential for oocyte survival and follicular development. Our previous study shows that transplantation of human bone marrow derived mesenchymal stem cell (hBM-MSC) in chemotherapy induced POI mouse ovary can reverse POI through correction of serum hormonal level, promote follicular generation in ovary, increase in granulosa cell population, and achieving pregnancy.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research