Alcohol's dysregulation of maternal-fetal IL-6 and p-STAT3 is a function of maternal iron status.

CONCLUSIONS: These findings suggest that alcohol-driven stimulation of the IL-6/JAK2/STAT3 pathway mediates the elevated hepcidin observed in the PAE dam and fetus. Normalization of these signals by IF suggests that dysregulated hepcidin is driven by alcohol's disruption of the IL-6/JAK2/STAT3 pathway. Prenatal dietary IF represents a potential therapeutic approach for PAE that warrants further investigation.
PMID: 31524964 [PubMed - as supplied by publisher]

Source: Alcoholism, Clinical and Experimental Research - September 15, 2019 Category: Addiction Authors: Saini N, Helfrich KK, Kwan STC, Huebner SM, Abazi J, Flentke GR, Blohowiak SE, Kling PJ, Smith SM Tags: Alcohol Clin Exp Res Source Type: research