The Role of Obesity in Obstructive Sleep Apnea (OSA)

This study shows the increase in the expression of leptins like Ob-Rb in Carotid .Images: Fluorescent (a-c) photomicrographs showing the effect of IH on Ob-Rb (a) and ERK 1/2 (b) expression in carotid body glomus cells. Note that Ob-Rb and ERK 1/2 are co-expressed in the same cells (c). Calibration mark in (a) represents 100 μm and applies to (a-c).Images: Western blots showing the presence of Ob-Rb (a) and Ob-R100 (b) in carotid bodies after IH. Note that IH significantly (*) decreases the protein level of Ob-Rb (a), while significantly (*) increasing the protein level of Ob-R100 (b) compared to normoxic controls (b). p values are indicated. n=5-6.This study will give the reader great insights on the molecular biology of OSA. Check it out: http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2487&context=etd.
Source: Neuromics - Category: Neuroscience Tags: immunoblotting Immunhistochemistry Obstructive sleep apnea LepRb antibody obesity Leptin Expression Ob-Rb antibody Western Blotting Immunfluorescence Source Type: news