Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.

Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation. Ultrasound Obstet Gynecol. 2019 Aug 13;: Authors: Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH Abstract OBJECTIVE: To examine the performance of the routine 11-13 weeks scan in detecting fetal non-chromosomal abnormalities. METHODS: This was a retrospective study of prospectively collected data from 100,997 singleton pregnancies attending for a routine ultrasound examination for fetal anatomy, according to a standardized protocol, at 11-13 weeks' gestation. All continuing pregnancies had an additional scan at 18-24 weeks and 71,754 had a scan at either 30-34 or 35-37 weeks. The final diagnosis of fetal abnormalities was based on the results of postnatal examination in the case of livebirths and on the findings of the last ultrasound examination in the cases of pregnancy termination, miscarriage or stillbirth. The performance of the 11-13 weeks scan in the detection of fetal abnormalities was determined. RESULTS: The study population contained 1,720 (1.7%) fetal abnormalities, including 474 (27.6%) detected in the first-trimester scan, 926 (53.8%) detected in the second-trimester scan and 320 (18.6%) detected in the third-trimester or postnatally. At 11-13 weeks' gestation we diagnosed all cases of acrania, alobar holoprosencephaly and encephalocele, tricuspid or pulmonary atresia, pentalogy of Cantrell and ectopi...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research

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