Assessment of long-term risks of secondary cancer in paediatric patients with brain tumours after boron neutron capture therapy
This study firstly explored the risks of secondary cancer in healthy organs of Chinese paediatric
patients with brain tumours after boron neutron capture therapy (BNCT). Three neutron beam
irradiation geometries (i.e. right lateral, top to bottom, posterior to anterior) were adopted in
treating patients with brain tumours under the clinical environment of BNCT. The concerned organs in
this study were those with high cancer morbidity in China (e.g. lung, liver and stomach). The
equivalent doses for these organs were calculated using Monte Carlo and anthropomorphic paediatric
phantoms with Chinese physiological features. The risk of secondary cancer, characterised by the
lifetime attributable risk (LAR) factor given in the BEIR VII report, was compared among the three
irradiation geometries. The results showed that the LAR was lower with the PA irradiation geometry
than with the two other irradiation geometries when the 2 cm diameter tumour was at a depth of 6 cm
on the right side...
Source: Journal of Radiological Protection - Category: Physics Authors: Xinxin Zhang, Changran Geng, Xiaobin Tang, Silva Bortolussi, Diyun Shu, Chunhui Gong, Yang Han and Shaojuan Wu Source Type: research
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