Insulin resistance, but not insulin response, during oral glucose tolerance test (OGTT) is associated to worse histological outcome in obese NAFLD

Obese subjects are at high risk of nonalcoholic fatty liver disease (NAFLD) and diabetes (T2D) due to insulin resistance (IR). Since high glucose levels are as toxic as lipids for hepatic metabolism, we hypothesize that altered response to oral glucose tolerance test (OGTT) is associated to more severe NAFLD with significant/advanced liver damage.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 9, 2019 Category: Nutrition Authors: Federica Coccia, Moira Testa, Gloria Guarisco, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Amalia Gastaldelli, Danila Capoccia Source Type: research