GSE126396 Characterisation of EZH2 and H3K27me3 genome-wide distribution in de novo transformed cells (ChIP-Seq)

In this study, we show that oncogenic signalling induces redistribution of EZH2 across the genome, which in turn misregulates key homeotic genes and corrupts the identity of neural cells. Characterisation of EZH2 direct targets in de novo transformed cells reveals that acquisition of tumorigenic potential is accompanied by a transcriptional switch involving de-repression of spinal cord-specifying HOX genes and concomitant silencing of the empty spiracles homologue EMX2, a key regulator of neurogenesis in the forebrain and negative regulator of neural stem cell proliferation. Our results suggest that by redistributing EZH2 across the genome, cancer cells subvert developmental transcriptional programs that specify normal cell identity and remove physiological breaks that normally restrain cell proliferation.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research