Bipolar depression: the clinical characteristics and unmet needs of a complex disorder.

Conclusions: Bipolar disorder is common among primary care patients presenting with depression; it is often treated exclusively in primary care. Clinicians should be alert for symptoms of bipolar disorder in undiagnosed patients, know what symptoms probabilistically suggest bipolar versus unipolar depression, have expertise in providing ongoing treatment to diagnosed patients, and be knowledgeable about managing common medication-related side effects and comorbidities. Prompt and accurate diagnosis is critical. PMID: 31311335 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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ConclusionsOur results provide patient-reported experiences about inpatient cardiac care in Alberta hospitals. The findings could inform quality improvement initiatives that are patient-centred.RésuméIntroductionLe Sondage sur les expériences d’hospitalisation des patients canadiens est un outil valide de mesure de l’expérience des patients adultes hospitalisés. Le couplage des sondages aux données administratives peut permettre d’examiner l’expérience des patients de groupes démographiques ou cliniques particuliers.MéthodesNous avons ex...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Carlos S. MorenoAbstractSOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ signaling. The SOX4 gene is frequently amplified and overexpressed in over 20 types of malignancies, and multiple lines of evidence support that notion that SOX4 is an oncogene. Its overexpression is due to both gene amplification and to activation of PI3K, Wnt, and TGFβ pathways that SOX4 regulates. SOX4 interac...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Journal of Geriatric OncologyAuthor(s): Guillaume Beinse, Delphine Reitter, Lauriane Segaux, Muriel Carvahlo-Verlinde, Benoit Rousseau, Christophe Tournigand, Tristan Cudennec, Marie Laurent, Pascaline Boudou-Rouquette, Elena Paillaud, Florence Canouï-Poitrine, Philippe Caillet, for the ELCAPA Study GroupAbstractBackgroundBecause of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with ca...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Naomi Fleming, Rowena CockerhamAbstractGeneral anaesthesia in obstetrics is reducing with a reported use in only 4% of caesarean sections in 2017–2018. Obstetric surgery is often urgent, requiring effective team communication and a rapid, focused preoperative assessment. Physiological changes of pregnancy increase the incidence of aspiration, desaturation and failed intubation. In addition, the rapidly evolving circumstances add additional stress, impacting on performance. Hypotension from aortocaval compr...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
In the last 3 years the numbers of forcibly displaced people around the world has reached a record high. Experiences of war, persecution, violence, torture, participating in the killing of others, disruptions of attachments, and emotional losses increase the risk for psychological distress and may contribute to the risk of developing psychiatric and substance abuse disorders. The authors review the existing psychiatric literature on refugees, discuss the sociological reasons that explain the recent crisis, describe the psychiatric consequences, the risk factors and protective factors of the refugee experience, narrate the ...
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Article Source Type: research
Gambling disorder is a pathologic condition, resulting from the interaction of multiple risk factors. Among these, dopamine neurotransmission is known for playing a significant role, as seen, for example, in patients using dopamine replacement therapy prescribed for Parkinson disease, in which gambling is considered to be iatrogenic. Considering this, together with the general mechanism of action of antipsychotic drugs, growing attention has recently been dedicated to Aripiprazole and to its partial dopaminergic agonism (reducing D2-receptor hyperactivation in the mesolimbic pathway and improving D2-receptor stimulation in...
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Case Report Source Type: research
Conclusions: Identifying the risk factors for psychiatric comorbidity in patients with substance dependence highlights the importance of developing a dual diagnosis service to meet the needs of this population.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Articles Source Type: research
Conclusions: Substance abuse affects male sexual functions negatively. There are limited studies about the effects of substance abuse on male sexual functions in our country. For this reason, there is a need for more extensive prospective studies.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Articles Source Type: research
Authors: Crabtree E, Brest B, Lewis RK Abstract Suicidality is a serious concern in this country. In the U.S. nearly 40,000 people die by suicide each year. It is the 10th leading cause of death. For those 15-24, it is the 2nd leading cause of death. Using data from the Add Health Longitudinal data set and data gathered from a local organization an examination of suicidality among African American youth was conducted. Given the trauma and low resourced situations many African American adolescents find themselves in, interventions are needed to address these health concerns before other issues such as education and ...
Source: Journal of Prevention and Intervention in the Community - Category: International Medicine & Public Health Tags: J Prev Interv Community Source Type: research
This study was designed to measure the perceived stress among Whites and Nonwhites using the Perceived Stress Scale, the Center for Epidemiologic Studies Depression Scale Revised, Positive and Negative Affect Scale (PANAS) and other behavioral indicators (diet and nutrition) to determine the overall well-being of college students. College students attending a mid-sized University in the Midwest completed an 80 item online survey. The results showed that thirty-six percent of the sample displayed depressive symptoms, 10% of the respondents endorsed high perceived stress and 56% reported experiencing moderate stress levels. ...
Source: Journal of Prevention and Intervention in the Community - Category: International Medicine & Public Health Tags: J Prev Interv Community Source Type: research
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