Treating stroke patients just 15 minutes earlier can save lives

Initiating stroke treatment just 15 minutes faster can save lives and prevent disability, according to a new UCLA-led study, published today inJAMA. The research also determined that busier hospitals — those that treat more than 450 people for stroke each year — have better outcomes than those that treat fewer than 400 stroke patients per year.Researchers at the  David Geffen School of Medicine at UCLA and five other institutions in the U.S. and Canada, examined data for 6,756 people who experienced ischemic strokes. The patients ’ median age was 71, and 51.2% were women.The researchers looked at stroke patients ’ treatment results in light of their “door-to-puncture” time — that is, the interval from their arrival at the hospital to the time their treatment began.The data showed that for every 1,000 people whose door-to-puncture time was 15 minutes sooner, 15 fewer died or were discharged to hospice care, 17 more were able to walk out of the hospital without assistance and 22 more could care for themselves after being discharged from the hospital. Researchers found that patients ’ median time from arriving at the hospital to the beginning of treatment was one hour, 27 minutes, and the median time from the onset of symptoms to treatment was three hours, 50 minutes.All of the patients in the study were treated with endovascular reperfusion therapy, which is used to treat strokes caused by a blockage in one of the major arter...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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CONCLUSION: The results suggest that these changes may contribute to the mechanotransduction disturbance evidenced in chagasic cardiomyopathy. PMID: 31433004 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Conclusion: This review suggests patients with RVO have an increased risk of cardiovascular events and all-cause mortality. More studies are needed to determine the highest risk periods for cardiovascular events and mortality after RVO and whether immediate cardiovascular evaluation and intervention will improve outcomes.
Source: RETINA - Category: Opthalmology Tags: Review Source Type: research
The Food and Drug Administration (FDA) has approved tafamidis meglumine (Vyndaqel) and tafamidis (Vyndamax) for the treatment of cardiomyopathy caused by transthyretin-mediated amyloidosis in adults. These are the first FDA-approved drug treatments for this rare genetic disorder.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
Abstract Ischemic colitis primarily affects the elderly with underlying disease, but it rarely occurs in young adults with risk factors, such as coagulopathy or vascular disorder. Moreover, it is extremely rare in the very young without risk factors. This paper presents a patient with ischemic colitis associated with heat stroke and rhabdomyolysis after intense exercise under high-temperature conditions. A 20-year-old man presented with mental deterioration after a vigorous soccer game for more than 30 minutes in sweltering weather. He also presented with hematochezia with abdominal pain. The laboratory tests reve...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
This study is registered with ClinicalTrials.gov, number NCT02119182.FindingsBetween Feb 26, 2014, and June 15, 2018, we recruited 450 patients with normal head CT scans (of whom 330 had negative MRI scans and 120 had positive MRI scans), 122 orthopaedic trauma controls, and 209 healthy controls. AUC for GFAP in patients with CT-negative and MRI-positive findings versus patients with CT-negative and MRI-negative findings was 0·777 (95% CI 0·726–0·829) over 24 h. Median plasma GFAP concentration was highest in patients with CT-negative and MRI-positive findings (414·4 pg/mL, 25–75th p...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Abstract Introduction: Various factors such as age and severity of the stroke have been deemed connected with risk of mortality in patients with acute ischemic brain stroke. The present study was performed with the aim of evaluating the role of electrocardiogram (ECG) changes in predicting the outcome of these patients. Methods: In this cohort study, patients who had presented to the emergency department of a teaching hospital during 1 year and were diagnosed with acute ischemic stroke were evaluated. Demographic data and 12-lead ECG findings of the patients were gathered and their relationship with 1-year mo...
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
Abstract Methadone poisoning has become more common in the pediatric population due to extensive use of methadone maintenance therapy (MMT). It is associated with decreased level of consciousness, coma, respiratory distress and cardiac intoxication. The cardiac complications have been reported to be QT prolongation, torsade de pointes, coronary artery disease, arrhythmia, stress cardiomyopathy and death. We herein report two pediatric patients with accidental methadone poisoning who developed stress cardiomyopathy and cardiac failure. The first case was a 4-yaer-old girl and the second one was an 18-month-old girl...
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Abhinav Sharma, Justin A. Ezekowitz
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Elodie M. Varin, Brent A. McLean, Julie A. LovshinAbstractPeople with type 2 diabetes (T2D) are at heightened risk for developing cardiovascular (CV) events, and cardiovascular disease (CVD) is the leading cause of premature death amongst adults with T2D. Unfortunately, historically, some anti-diabetes agents were implicated in worsening cardiovascular function, despite improving glycemic and metabolic control. Accordingly, over a decade ago, health regulatory bodies modified approval requirements for novel anti-diabetes pharmac...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Rimesh Pal, Rajsmita Bhattacharjee, Debajyoti Chatterjee, Sanjay Kumar Bhadada, Anil Bhansali, Pinaki Dutta
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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