Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven nonalcoholic fatty liver disease

With the growing prevalence of childhood obesity, pediatric non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease in children and adolescents in Western countries [1 –3]. NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis, non-alcoholic steatohepatitis (NASH), advanced fibrosis and, ultimately, cirrhosis [3,4]. Compelling evidence indicates that NAFLD also has serious health consequences outside of the liver and is strongly asso ciated with an increased risk of cardiovascular disease and abnormal glucose tolerance (prediabetes and type 2 diabetes) [5–7].

Source: Journal of Hepatology - July 3, 2019 Category: Gastroenterology Authors: Valerio Nobili, Alessandro Mantovani, Stefano Cianfarani, Anna Alisi, Antonella Mosca, Maria Rita Sartorelli, Claudio Maffeis, Rohit Loomba, Christopher D. Byrne, Giovanni Targher Source Type: research