Molecular Genetics and the Role of Molecularly Targeted Agents in Metastatic Colorectal Carcinoma

ConclusionsAlterations in several oncogenes are associated with CRC, among those RAS, BRAF, and HER2 are of current clinical importance. Chemotherapy drugs, along with vascular endothelial growth factor or epidermal growth factor receptor monoclonal antibodies, are proven to be efficient with manageable toxicity profiles in metastatic CRC. Additional researches on Her-2-directed therapy, BRAF-targeted agents, immunotherapeutic, and newer molecularly targeted agents are needed for further improvement in outcome.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research