Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders

Publication date: Available online 2 July 2019Source: Pharmacological ResearchAuthor(s): Maria Rosaria Domenici, Antonella Ferrante, Alberto Martire, Valentina Chiodi, Rita Pepponi, Maria Teresa Tebano, Patrizia PopoliAbstractAdenosine A2A receptor (A2AR) is a G-protein coupled receptor that regulates several important functions in the central nervous system. Large amount of preclinical data suggests that the A2AR could represent a target for the development of new therapeutic strategies for different neuropsychiatric conditions. In this review we will recapitulate and discuss the most relevant studies on the role of A2ARs in neurodegenerative, neurodevelopmental and psychiatric diseases, which led to suggest a therapeutic use of A2AR agonists in certain diseases (Niemann-Pick disease, autism-spectrum disorders, schizophrenia) and A2AR antagonists in others (Alzheimer’s disease, Parkinson’s disease, attention-deficit hyperactivity disorder, fragile X syndrome, depression, anxiety). Moreover, we will try to analyze which are the main obstacles to the conduction of clinical trials with A2AR ligands for the treatment of neuropsychiatric disease.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Carlos S. MorenoAbstractSOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ signaling. The SOX4 gene is frequently amplified and overexpressed in over 20 types of malignancies, and multiple lines of evidence support that notion that SOX4 is an oncogene. Its overexpression is due to both gene amplification and to activation of PI3K, Wnt, and TGFβ pathways that SOX4 regulates. SOX4 interac...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Authors: Crabtree E, Brest B, Lewis RK Abstract Suicidality is a serious concern in this country. In the U.S. nearly 40,000 people die by suicide each year. It is the 10th leading cause of death. For those 15-24, it is the 2nd leading cause of death. Using data from the Add Health Longitudinal data set and data gathered from a local organization an examination of suicidality among African American youth was conducted. Given the trauma and low resourced situations many African American adolescents find themselves in, interventions are needed to address these health concerns before other issues such as education and ...
Source: Journal of Prevention and Intervention in the Community - Category: International Medicine & Public Health Tags: J Prev Interv Community Source Type: research
This study was designed to measure the perceived stress among Whites and Nonwhites using the Perceived Stress Scale, the Center for Epidemiologic Studies Depression Scale Revised, Positive and Negative Affect Scale (PANAS) and other behavioral indicators (diet and nutrition) to determine the overall well-being of college students. College students attending a mid-sized University in the Midwest completed an 80 item online survey. The results showed that thirty-six percent of the sample displayed depressive symptoms, 10% of the respondents endorsed high perceived stress and 56% reported experiencing moderate stress levels. ...
Source: Journal of Prevention and Intervention in the Community - Category: International Medicine & Public Health Tags: J Prev Interv Community Source Type: research
Publication date: Available online 22 August 2019Source: Neuroscience ResearchAuthor(s): John M. Andraka, Naveen Sharma, Yannick MarchalantAbstractMost neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, demonstrate preceding or on-going inflammatory processes. Therefore, discovering effective means of counteracting detrimental inflammatory mediators in the brain could help alter aging-related disease onset and progression. Fish oil and marine-derived omega-3, long-chain polyunsaturated fatty acids (LC n-3) have shown promising anti-inflammatory effects both systemically and centrally. More...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Publication date: 21 August 2019Source: Neuron, Volume 103, Issue 4Author(s): Leonard K. KaczmarekMutations in voltage-dependent sodium channels cause severe autism/intellectual disability. In this issue of Neuron, Spratt et al. (2019) show that lowering expression of Nav1.2 channels attenuates backpropagation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent synaptic plasticity.
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
– Somryst app by Pear Therapeutics Digital therapeutics have potential but commercial success unproven (Vantage): “Developing drugs to treat disorders of the central nervous system is famously fraught with difficulty. Several companies, including Pear Therapeutics and Dthera, are taking a wildly different approach: digital therapeutics. These are pieces of software designed to treat disease that are regulated, prescribed and even paid for as if they were drugs … Pear is so far the only company to have brought a digital therapeutic to market – but it is by no means the only company in this space. Ak...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Akili Interactive AKL-T01 Click Therapeutics cognitive dysfunction digital therapeutics Dthera Pear Therapeutics Somryst Source Type: blogs
ConclusionAlmost six out of ten VS patients had fatigue, significantly higher than the control group. Interest and focus on fatigue in VS patients can improve the patient ’s QoL.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Authors: Fischer Fumeaux CJ, Morisod Harari M, Weisskopf E, Eap CB, Epiney M, Vial Y, Csajka C, Bickle Graz M, Panchaud A Abstract Introduction: Depression affects 300 million individuals worldwide. While selective serotonin reuptake inhibitors (SSRI) are one of the first-line pharmacological treatments of major depression in the general population, there is still uncertainty regarding their potential benefits and risks during pregnancy. Areas covered: Outcomes requisite for a proper risk/benefit assessment of SSRI in pregnancy and lactation were considered: (a) potential risks associated with untreated depression,...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Conclusions: A sizable number of postpartum women experience clinically significant postpartum-specific intrusive thoughts and utilise neutralising strategies, especially in the context of postpartum depressive symptoms. Depressive symptoms have the most influence on maternal responsiveness but it is also important to target intrusive thoughts and OC symptoms in the context of postpartum depression to promote the welfare of new mothers and their offspring. PMID: 31431052 [PubMed - as supplied by publisher]
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
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