Minocycline for Symptom Reduction during Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial

The most debilitating symptoms during oxaliplatin-based chemotherapy in patients with colorectal cancer (CRC) are neuropathy and fatigue. Inflammation has been suggested to contribute to these symptoms, and the anti-inflammatory agent minocycline is safe and readily available.

Source: Journal of Pain and Symptom Management - June 25, 2019 Category: Palliative Care Authors: Xin Shelley Wang, Qiuling Shi, Nishin Bhadkamkar, Charles S. Cleeland, Araceli Garcia-Gonzalez, Jonathan Aguilar, Cobi Heijnen, Cathy Eng Source Type: research