Nꭃ-nitro-L-arginine methyl model of pre-eclampsia elicits differential IBA1 and EAAT1 expressions in brain

Publication date: Available online 25 June 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Olayemi Kafilat Ijomone, Philemon Shallie, Thajasvarie NaickerAbstractPre-eclampsia (PE) is a pregnancy syndrome associated with an increased risk of both the mother and the baby developing cardiovascular disorders later in life. It is widely accepted that women with severe PE develop a neurological impairment however studies have revealed that the mother and baby are at jeopardy for a neurological deficit later in life. The present study examined expression of Ionized calcium binding adaptor molecule 1 (IBA1) and Excitatory amino acid transporter 1 (EAAT1) as neuroinflammatory markers in an Nꭃ-nitro-L-arginine methyl (L-NAME) model of early- and late-onset (EOPE/ LOPE) PE-like syndrome in rat models. Forty-five adult nulliparous pregnant Sprague-Dawley rats were used for this experiment. They were divided into Control, EOPE and LOPE groups. Administration of L-Name was done between gestational days 8-17 for the treated groups. Animals were sacrificed at gestational day (GD) 19, post-natal day (PND) 1 and 60 and the brain excised for further analysis. Our study confirmed L-NAME induced PE-like symptoms in rat models as evidenced by significant increase in systolic blood pressure and urine protein compared with Control. There was upregulation of IBA1 expression and increased microglial activation in the brain of PE rat models assessed at gestational day 19, post-natal day 1 and ...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

Related Links:

Yesterday's post was the news and media from the last week and a bit.Here is the research, statistics and reports.ResearchPlanned earlier delivery for late pre-eclampsia may be better for mothers (NIHR Signals)Review of a study in the LancetInduction recommended for women still pregnant at 41 weeks (Guardian)Report of research from the SWEPIS study, published in theBMJ, .Health service programmesICON (Babies cry, you can cope) - programme launched in North Yorkshire to help parents manage normal infant crying and prevent abusive head injuries caused by shakingReportsBetter for women report (RCOG): improving the health and ...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
ConclusionsOur findings do not support clear associations between antenatal magnesium sulphate for beneficial indications and adverse neonatal outcomes. Further large, high-quality studies (prospective cohorts or individual participant data meta-analyses) assessing specific outcomes, or the impact of regimen, pregnancy, or birth characteristics on these outcomes, would further inform safety recommendations. PROSPERO: CRD42013004451.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Authors: Choi M, Butler E, Clarke A, Girard LP, Gibson P, Skeith L Abstract Introduction: Systemic lupus erythematosus (SLE)-related thrombocytopenia during pregnancy and the postpartum period have been associated with adverse pregnancy outcomes and perinatal complications. In this case report, we present two SLE patients with thrombocytopenia emergencies secondary to HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome and thrombotic thrombocytopenic purpura (TTP).Areas covered: The first case involved a 26-year-old woman, G1P0 at 26 weeks gestation (GA), with high-titre antiphospholipid antibodie...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Authors: Berger H, Gagnon R, Sermer M Abstract OBJECTIVES: This guideline reviews the evidence relating to the diagnosis and obstetrical management of diabetes in pregnancy. OUTCOMES: The outcomes evaluated were short and long-term maternal outcomes including pre-eclampsia, Caesarean section, future diabetes and other cardiovascular complications; and fetal outcomes including congenital anomalies, stillbirth, macrosomia, birth trauma, hypoglycemia and long-term effects. EVIDENCE: Published literature was retrieved through searches of PubMed and The Cochrane Library using appropriate controlled vocabulary (M...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Abstract Background: The improvement in surgical techniques has contributed to an increasing number of childbearing women with complex congenital heart disease (CCC). However, adequate counseling about pregnancy in this situation is uncertain, due to a wide variety of residual cardiac lesions. Objectives: To evaluate fetal and maternal outcomes in pregnant women with CCC and to analyze the predictive variables of prognosis. Methods: During 10 years we followed 435 consecutive pregnancies in patients (pts) with congenital heart disease. Among of them, we selected 42 pregnancies in 40 (mean age of 25.5 ± 4.5 years) pt...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: The improvement in surgical techniques has contributed to an increasing number of childbearing women with complex congenital heart disease (CCC). However, adequate counseling about pregnancy in this situation is uncertain, due to a wide variety of residual cardiac lesions. Objectives: To evaluate fetal and maternal outcomes in pregnant women with CCC and to analyze the predictive variables of prognosis. Methods: During 10 years we followed 435 consecutive pregnancies in patients (pts) with congenital heart disease. Among of them, we selected 42 pregnancies in 40 (mean age of 25.5 ± 4.5 years) pt...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
This study asses...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Publication date: December 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 8Author(s): Alexandra Pouliot, Riham Elmahboubi, Catherine AdamAbstractObjectivesAt 1 Canadian university hospital, pregnant women were routinely screened for gestational diabetes mellitus (GDM) with a 75-g oral glucose tolerance test (OGTT). Diagnostic plasma glucose thresholds were as follows: fasting: ≥5.3 mmol/L, 1 h: ≥10.6 mmol/L and 2 h: ≥9.0 mmol/L. In 2015, diagnostic thresholds were reduced to those recommended by the International Association of Diabetes in Pregnancy Study Group (IADPSG) as follows: fasting: ≥5.1 mmo...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine gro...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Conclusion: Expectant fathers should be screened for symptoms of Couvade Syndrome throughout the pregnancy in order to better support the familial unit. PMID: 31769327 [PubMed - as supplied by publisher]
Source: Journal of Psychosomatic Obstetrics and Gynaecology - Category: OBGYN Tags: J Psychosom Obstet Gynaecol Source Type: research
More News: Babies | Brain | Calcium | Cardiology | Cardiovascular | Chemistry | Heart | Neurology | Neuroscience | Pre-eclampsia | Pregnancy | Study | Women