Evaluation and binding site determination of microtubule PET tracers [11C]MPC-6827 and [11C]HD-800 in cancer cell lines

Conclusions: We demonstrated specific bindings of [11C]MPC-6827 and [11C]HD-800 in breast cancer, GBM, and prostate cancer cell lines. Both tracers showed binding to taxane and colchicine sites of microtubule in MAD-MB-231 cells. This may be an advantage of these tracers for favoring high signal to noise ratio for in vivo imaging in cancer animal models. Combined with the previously established BBB permeability and in vivo binding specificity, [11C]MPC-6827 and [11C]HD-800 can be potential radiotracers for in vivo preclinical imaging of central and periphery cancers using PET. Research Support: Diane Goldberg Foundation (NYSPI/CUMC) and WFSM CTSA TIP (UL1TR001420) References: 1. Wang X-F. et.al. J. Med. Chem. 2014, 57, 1390-1402; Cui M-T. et.al., J. Med. Chem., 2017, 60, 5586. 2. Kumar J.S.D. et al., J. Med. Chem., 2018, 61, 2118-2120; Solingapuram Sai K. K. et.al., ACS Med Chem Lett., 2018, 78, 108-115.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: KUMAR, D., Hines, J., Norman, S., Prabhakaran, J., Mann, J., Mintz, A., Solingapuram Sai, K. K. Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research