Heart ketone uptake reserve in diabetic ZDF rats with an acute ketone ester supplementation: a [11C]-acetoacetate rest-stress study

Conclusions: Ketone uptake reserve is impaired under stress in type II diabetes ZDF rats compared to CTRL rats. Interestingly, ketone ester supplementation decreases [11C]-acetoacetate uptake in the rest condition improving the uptake reserve in ZDF but not in CTRL rats. This is the first reported study of the in vivo heart ketone uptake reserve in an animal model of type II diabetes. [asterisk]Mudaliar S et al. Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis. Diabetes Care. 2016;39:1115-22.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Croteau, E., Rousseau, E., Prud'Homme, P., Cunnane, S., Dumulon-Perreault, V., Archambault, M., Sarrhini, O., Richard, M., Tremblay, S., Guerin, B., Lecomte, R. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research