Identification of 22 novel loci associated with  urinary biomarkers of albumin, sodium, and potassium excretion

Urine biomarkers reflecting kidney function and handling of dietary sodium and potassium are strongly associated with several common diseases including chronic kidney disease, cardiovascular disease, and diabetes mellitus. Knowledge about the genetic determinants of these biomarkers may shed light on pathophysiological mechanisms underlying the development of these diseases. We performed genome-wide association studies of urinary albumin: creatinine ratio (UACR), urinary potassium: creatinine ratio (UK/UCr), urinary sodium: creatinine ratio (UNa/UCr) and urinary sodium: potassium ratio (UNa/UK) in up to 218,450 (discovery) and 109,166 (replication) unrelated individuals of European ancestry from the UK Biobank.

Source: Kidney International - March 10, 2019 Category: Urology & Nephrology Authors: Daniela Zanetti, Abhiram Rao, Stefan Gustafsson, Themistocles L. Assimes, Stephen B. Montgomery, Erik Ingelsson Tags: Clinical Investigation Source Type: research