Deleterious synergistic effects of distress and surgery on cancer metastasis: Abolishment through an integrated perioperative immune-stimulating stress-inflammatory-reducing intervention.
Deleterious synergistic effects of distress and surgery on cancer metastasis: Abolishment through an integrated perioperative immune-stimulating stress-inflammatory-reducing intervention.
Brain Behav Immun. 2019 Mar 06;:
Authors: Matzner P, Sorski L, Haldar R, Shaashua L, Benbenishty A, Lavon H, Azan Y, Sandbank E, Melamed R, Rosenne E, Ben-Eliyahu S
Abstract
The perioperative period holds disproportionate impact on long-term cancer outcomes. Nevertheless, perioperative interventions to improve long-term cancer outcomes are not clinical routines, including perioperative stress-reducing or immune-stimulating approaches. Here, mimicking the clinical setting of pre-operative distress, followed by surgery, we examined the separate and combined effects of these events on the efficacy of pre-operative immune stimulation in rats and mice, and on post-operative resistance to tumor metastasis of the syngeneic mammary adenocarcinoma MADB106 in F344 rats and the CT26 colon carcinoma in Balb/C mice. The novel immune stimulating agents, GLA-SE or CpG-C (TLR-4 and TLR-9 agonists, respectively), were employed pre-operatively. Sixteen hours of pre-operative behavioral stressors (i) lowered CpG-C induced plasma IL-12 levels, and reduced resistance to MADB106 and CT-26 experimental metastases, and (ii) worsened the deleterious effects of laparotomy on metastasis in both tumor models. In rats, these effects of pre-operative stress were further studied ...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Matzner P, Sorski L, Haldar R, Shaashua L, Benbenishty A, Lavon H, Azan Y, Sandbank E, Melamed R, Rosenne E, Ben-Eliyahu S Tags: Brain Behav Immun Source Type: research
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