Patient attitudes about non-medical switching to biosimilars: results from an online patient survey in the United States.

CONCLUSIONS: Patients reported multiple concerns about NMS that might impact treatment outcomes, and many of the patients who non-medically switched in this survey missed treatments. Future studies should be conducted on patient expectations and experiences with NMS to understand the impact on healthcare delivery, treatment persistency, and patient outcomes. The patient perspective and experience should be considered by decision-makers when developing coverage policies for biosimilar medications and associated communication strategies. PMID: 30618353 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Publication date: Available online 21 January 2020Source: Genes &DiseasesAuthor(s): W.E.I. Zilun, Y.A.N.G. Yining, L.I. Qiaoling, Y.I.N. Yong, W.E.I. Zhonghai, Z.H.A.N.G. Wenfeng, M.U. Dan, N.I. Jie, S.U.N. Xuan, X.U. BiaoAbstract and KeywordsHypertension (HT) is the most common public-health challenge and shows a high incidence around the world. Cardiovascular diseases are the leading cause of mortality and morbidity among the elderly (age> 65 years) in the United States. Now, there is widespread acceptance of the causal link between HT and acute myocardial infarction (MI). This is the first data-mining study to id...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Taylor P. Kohn, Jaden R. Kohn, Ryan C. Owen, R. Matthew Coward
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Alberto Ferlin
Source: European Urology - Category: Urology & Nephrology Source Type: research
D'Anci and colleagues' systematic review (1) is a welcome addition to the literature on the prevention and treatment of suicidality, a major public health crisis in the United States. However, their criterion of including only double-blind, randomized ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
ConclusionMSUS is powerful in the detection of early RA regarding synovitis, joint effusion, tenosynovitis, and bone erosions, which were correlated with clinical and laboratory parameters.
Source: Academic Radiology - Category: Radiology Source Type: research
The objective of this systematic review was to evaluate use and effectiveness of pre-operative education with respect to post-operative opioid use and management of pain in the orthopaedic setting. Electronic searches were conducted in Ovid/Medline and SCOPUS to identify articles that discuss pre-operative opioid education and its effects on post-operative pain scores and prescription fulfillment. Non-orthopaedic studies were included for comparison. Eleven studies met inclusion criteria, 3 of which were retrospective reviews of large (>1000) post-surgical cohorts, and 8 of which were randomized controlled studies that ...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
CONCLUSION: As a result of the study the relationship of the alleles/genotypes of the IL1B rs16944, IL10 rs1800872, CTLA4 rs3087243, NFKB1 rs28362491 polymorphic loci and the TNFA rs1800629*A - LTA rs909253*G haplotype with the methotrexate efficacy in JIA was established (taking into account the differences by sex). PMID: 31958219 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Publication date: February 2020Source: Journal of the Academy of Nutrition and Dietetics, Volume 120, Issue 2Author(s): Mindy A. Patterson, Madhura Maiya, Maria L. StewartAbstractResistant starch (RS; types 1 to 5) cannot be digested in the small intestine and thus enters the colon intact, with some types capable of being fermented by gut microbes. As a fiber, types 1, 2, 3, and 5 are found naturally in foods, while types 2, 3, and 4 can be added to foods as a functional ingredient. This narrative review identifies RS content in whole foods commonly consumed in the United States. Scientific databases (n=3) were searched by...
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Abstract AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis (UC), Crohn's disease (CD) and Both t...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
AbstractInfliximab biosimilar (CT-P13/infliximab-dyyb; Remsima®, Inflectra®) is approved in several countries for use in all indications for which reference infliximab (Remicade®) is approved, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis. Clinical data contributing to the EU approval of infliximab biosimilar were obtained from two pivotal double-blind clinical trials in patients with AS (PLANETAS) or RA (PLANETRA). Infliximab biosimilar demonstrated equivalence to reference infliximab in terms of its pharmacokine...
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
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