Risk of adverse events in patients prescribed long ‐term opioids: a cohort study in the UK Clinical Practice Research Datalink

This study examined the risks of a range of adverse events in a large cohort of patients prescribed long‐term opioids using the UK Clinical Practice Research Datalink.MethodsPatients with musculoskeletal conditions starting a new long ‐term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002‐2012 were included. Primary outcomes: major trauma and intentional overdose (any). Secondary outcomes: addiction (any), falls, accidental poisoning, attempted suicide/self‐harm, gastrointestinal pathology a nd bleeding, and iron deficiency anaemia. ‘Control’ outcomes (unrelated to opioid use): incident eczema and psoriasis.Results98,140 new long ‐term opioids users (median age 61, 41% male) were followed for (median) 3.4 years. Major trauma risk increased from 285 per 10,000 person‐years without long‐term opioids to 369/10,000 for a long‐term opioid episode (
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

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Publication date: March–April 2020Source: Journal of Applied Developmental Psychology, Volume 67Author(s): Claudine FoxAbstractThis paper reports a study that adopted age-appropriate terminology to investigate 6–11-year-old children's attitudes towards mental illness (N = 120). The study utilized a semi-structured interview technique and card selection tasks to assess the children's attitudes to individuals diagnosed with different mental illnesses (anorexia nervosa, depression and dementia). Their attitudes were measured in terms of social distance, social functioning, emotional response and trait at...
Source: Journal of Applied Developmental Psychology - Category: Child Development Source Type: research
The objective of this work was to evaluate the physicochemical characteristics and technological functional properties of okara flours (OFs) obtained by different drying processes in forced air oven (FAD at 40, 50, 60, and 70 °C), microwave (MWD), and freeze drying (FRD). The OFs showed acidity range of 3–5.7 mEq NaOH/100 g, pH of 5.4–5.9, soluble solid of 0.6–1.3 ºBrix, luminosity of 78–85, and good technological functional properties (MWD-OF and FRD-OF showed ↑oil absorption capacity and ↑emulsifying capacity and FRD-OF showed foam capacity). The FAD70-OF, MWD-OF, and FRD-OF...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
CONCLUSIONS: The clinical polymorphism effectiveness outlined therein will be assured by diagnostic improvements suitable for driving treatment decisions. In light of our experimental results and literature data, the analysis of the SLCO1B1 T521C variant will allow clinicians to take advantage from a better treatment planned for their patients in order to minimize neuromuscular pain and maximize benefits. PMID: 31957862 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Nakamura K, Sugai A, Saji E, Kasuga K, Onodera O Abstract Myositis generally affects the proximal muscles. However, we herein report a case of a 48-year-old woman with intractable myositis affecting the intrinsic muscles of the hands. Her myositis, which developed in childhood, was refractory to treatment with steroids and several immunosuppressants, causing walking disability. After experiencing pain and swelling in the hands for six months, she was diagnosed with myositis of the intrinsic muscles of the hands and tested positive for the anti-signal recognition particle antibody. Intravenous immunoglobuli...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Anna ZawadaAbstractWith the help of Mössbauer investigations, it was found that tetrahedral coordination is present in the alkali silicate glass system for both Fe2+ and Fe3+ in oxidising molten glass. The reduction process changes the coordination number of iron from 4 to 6. It is clear that the iron content has a much stronger influence on the properties than the redox state. In lower temperatures, the difference between reducing and oxidising conditions can be clearly observed, which at high temperatures lies within the mea...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 February 2020Source: Life Sciences, Volume 243Author(s): Karine Cestaro Mesquita, Thinali Sousa Dantas, Paulo Goberlânio de Barros Silva, Maria Imaculada de Queiroz Rodrigues, Ana Paula Negreiros Nunes Alves, Mário Rogério Lima Mota, Fabrício Bitu SousaAbstractThe present study aimed to evaluate the healing process of ulcers in the jugal mucosa of Wistar rats treated with abatacept. The rats were randomly assigned to four groups: saline-treated control (0.3 mL/kg) abatacept-treated groups at dosages of 3.2, 8.0 and 20.0 mg/kg/week. After two weeks of subcutaneous (S...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 20 January 2020Source: Life SciencesAuthor(s): Nada F. Abo El-Magd, Salma M. ErakyAbstractAimDrug-induced liver and kidney injuries are worldwide problems that cause restrictions in the use of drugs. The injury is highly mediated by oxidative stress and inflammation pathways. So, demonstrating the role of the natural compound (Vit.D) on the prevention of acetaminophen (APAP) overdose toxicity and the molecular mechanism through NrF2/BACH1/HO-1 pathway is promising.ExperimentalMale Sprague Dawley rats (40 rats) were divided randomly into 4 groups: Normal, APAP, APAP+Vit.D (500 IU/kg) and...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 21 January 2020Source: Chemical Engineering JournalAuthor(s): Leiduo Lai, Hongyu Zhou, Heng Zhang, Zhimin Ao, Zhicheng Pan, Qixuan Chen, Zhaokun Xiong, Gang Yao, Bo LaiAbstractNatural titanomagnetite, a potential catalyst, was used as a peroxydisulfate (PDS) activator for the removal of atrazine (ATZ) in water for the first time. The surface ≡Fe(Ⅱ) and ≡Fe(III) of titanomagnetite was certified as the active components by XRD and XPS analyses. ATZ removal showed a strong dependence on the titanomagnetite concentration (0-10 g/L), PDS concentration (0-10 mM) and the initial pH...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 May 2020Source: Chemical Engineering Journal, Volume 387Author(s): Yuan Gao, Hong-Fei Xiang, Xiao-Xiong Wang, Kang Yan, Qi Liu, Xin Li, Rui-Qiang Liu, Miao Yu, Yun-Ze LongAbstractIn situ fiber deposition technology has shown great excellence in visceral hemostasis. In recent years, minimally invasive surgery has been widely welcomed by patients because of its small trauma, light pain and rapid recovery. In the treatment of minimally invasive surgical wounds, fiber deposition has the advantages of fast, convenient, disassemble free and low toxicity. However, due to the conductive nature of the human body...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 May 2020Source: Chemical Engineering Journal, Volume 387Author(s): Bu-De Xu, De-Chang Li, Ting-Ting Qian, Hong JiangAbstractGiven its high activity and nontoxicity, nanoscale zero-valent iron (nZVI) has been intensively used to remediate the groundwater contaminated by trichloroethylene (TCE). However, the long-term stability of nZVI could be impaired by aging and natural organic matter. Herein, a montmorillonite-supported sulfurated nZVI (S-nZVI/MMT) was successfully synthesized, which exhibited robust activity and stability under environmental conditions through the interlayer interaction of MMT. The ...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
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