Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery.

Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery. Drug Deliv. 2018 Nov;25(1):1865-1876 Authors: Cui L, Wang Y, Liang M, Chu X, Fu S, Gao C, Liu Q, Gong W, Yang M, Li Z, Yu L, Yang C, Su Z, Xie X, Yang Y, Gao C Abstract Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Here we constructed a natural high-density lipoprotein particle (HDL)-based drug delivery system with the dual-modification of T7 and dA7R peptide ligand (T7/dA7R-HDL) to achieve the above goals. HDL, the smallest lipoprotein, plays a biological role and is highly suitable as a platform for delivering imaging and therapeutic agents. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma. dA7R is a d-peptide ligand of vascular endothelial growth factor receptor 2 (VEGFR 2) overexpressed on angiogenesis, presenting excellent glioma-homing property. 10-Hydroxycamptothecin (HCPT), a hydrophobic anti-cancer drug, was used as the model drug in this study. By combining the dual-targeting delivery effect...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research