On the Links between Arterial and Venous Thrombosis: A Comparative Genomic Analysis of Cardiovascular Disease and Venous Thromboembolism

Discussion and conclusion: our comparative analyses provide new data on how venous and arterial thrombosis differ at a transcriptional level. Specifically, we identified a set of 473 genes whose expression levels were consistently changed in both CVD and VTE, and 124 genes with divergent expression levels between these conditions. The prominence of pathways associated with hemostasis, innate immunity and neutrophil function in both CVD and VTE are in line with the concept of immunothrombosis in the pathogenesis of thrombotic disorders. The clustering of MI, IS and PAOD compared to VTE and CS is coherent with the concept that CS is caused by thrombi formed in a different microenvironment than IS. Additional studies are warranted on the role of these genes and pathways in the pathogenesis of CVD and VTE, as well as on the biological relevance of these thrombosis-specific gene expression signatures in other thrombotic disorders.DisclosuresDe Paula: Hematology and Transfusion Medicine Center, University of Campinas: Employment.
Source: Blood - Category: Hematology Authors: Tags: 331. Pathophysiology of Thrombosis: Poster III Source Type: research