Treatment of Immune Thrombocytopenia (ITP) with Eltrombopag (EPAG) in Patients Who Did and Did Not Receive Prior Rituximab (Ritux): A Post-Hoc Analysis of the Extend Study

Background: ITP is an acquired autoimmune disorder. Second-line treatment options include EPAG, romiplostim (both stimulate platelet production), ritux (a monoclonal anti-CD20 antibody that causes temporary but complete depletion of peripheral B cells), splenectomy (spl), and other immunosuppressive agents. This subanalysis of EXTEND, a global, open-label, extension study, evaluated long-term EPAG in adults with ITP of ≥6 months' duration according to prior ritux use.Aims: Describe efficacy and safety of EPAG in ITP patients (pts) according to prior ritux use.Methods: In EXTEND (Wong et al. Blood 2017;130:2527-36), pts started EPAG at 50 mg/day, with dose adjusted as required to achieve platelet counts of 50-200x109/L.Results: Of 302 pts in EXTEND, 70 (23%) had previously received ritux. Of these pts, mean±SD age was 53±14 years (yrs), median (range) time since diagnosis was 71.3 (12-362) months, 67% were splenectomized, 61% were female, 76% had baseline platelet counts <30x109/L, 100% had received prior ITP therapy (66% received ≥5 prior therapies), and median (range) time since last ritux was 1.6 (52 days-5.1 yrs) yrs. Of 232 (77%) pts who had not received prior ritux, mean±SD age was 48±16 yrs, median (range) time since diagnosis was 51.6 (9-552) months, 29% were splenectomized, 68% were female, 68% had platelet counts <30x109/L, and 92% had received prior ITP treatment (13% received ≥5 prior therapies).Mean (range) EPAG daily dos...
Source: Blood - Category: Hematology Authors: Tags: 311. Disorders of Platelet Number or Function: Poster I Source Type: research