Performance of Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS-TBNA) with Rapid On-Site Evaluation (ROSE) in the pathological subtyping and molecular testing of non-small cell lung cancer (NSCLC) at a UK institute

Conclusions: Our study has illustrated EBUS-TBNA cytology with ROSE can achieve accurate subtyping of NSCLC and a high proportion of sufficient material for molecular analysis. In addition our NSCLC-NOS rate (8.6%)is lower than UK national average (9%) in 2017.References: 1- Royal College of Physicians. National Lung Cancer Audit annual report 2017
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research

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Publication date: Available online 21 September 2019Source: Carbohydrate PolymersAuthor(s): Yongbo Ding, Ying Liang, Feijun Luo, Qunfu Ouyang, Qinlu LinAbstractThe digestibility properties and structural changes of retrograded starch (RS3) induced by ultrasonic treatment (UT) were investigated. The digestion profiles showed that UT increased the slowly digestible starch (SDS) or resistant starch (RS) of RS3 as an effective green process, corresponding to a change in hydrolysis kinetic parameters (equilibrium starch hydrolysis percentage and kinetic constant). SEM analysis showed that ultrasound led to breakage of RS3 parti...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 September 2019Source: Process BiochemistryAuthor(s): Velusamy Arumugam, Manigandan Venkatesan, Selvakumar Murugesan, Rathinam Ayyasamy, Saravanan Ramachandran, Umamaheswari Sundaresan, Arivalagan PugazhendhiAbstractMarine ascidians contain potential bioactive compounds, which exhibit significant pharmacological activities. In the present study, the MeOH extract of Didemnum sp. was subjected to FT-IR, GC-MS analysis, the possible interactions with EGFR through docking analysis and in vitro cytotoxic activity against KB (Human oral cancer) cell line were also studied. The FT-IR analysis ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
[Vanguard] As part of ways to reduce the rising spate of cervical cancer cases in the country, Sebeccly Cancer Care organization launched the TimeToScreen 2019 programme on the 19th of September, 2019 at the Zenith House, Iga-Idunganran Primary Healthcare Centre, Iga-Idunganran, Lagos Island.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionThose who use other cancer patients’ experiences to aid in their surgical decision-making enjoy a higher satisfaction with their decision.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionAn effort to identify patients with sarcomatosis who are predicted to have a complete cytoreduction should occur when these patients are evaluated. Patients with a complete resection and a sarcoma-specific HIPEC may have prolonged disease-free survival. No other treatments for these patients have been described.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 21 September 2019Source: European Journal of Surgical OncologyAuthor(s): Sang-Ho Jeong, Rock Bum Kim, Sun Yi Park, Jiho Park, Eun-Jung Jung, Young-tae Ju, Chi-Young Jeong, Miyeong Park, Gyung Hyuck Ko, Dae Hyun Song, Hyun Min Koh, Woo-Ho Kim, Han-Kwang Yang, Young-Joon Lee, Soon-Chan HongAbstractBackgroundRecently, researchers have tried to predict patient prognosis using biomarker expression in cancer patients. The aim of this study was to develop a nomogram predicting the 5-year recurrence-free probability (RFP) of gastric cancer patients using prognostic biomarker gene expression.Metho...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusion and Perspectives The IL-6/JAK/STAT signaling cascade plays a dominant role in skeletal muscle pathophysiology. IL-6 autocrine, paracrine, and endocrine functions assign to its downstream effectors pivotal importance in skeletal muscle-wasting-associated diseases and other multiple system diseases where muscle acts in communication with other organs. Targeting the components of the JAK/STAT pathway recently emerged as a strategic approach for the treatment of inflammatory diseases and human cancer. This review highlights the opposite outcomes on muscle biology caused by the amount of local and systemic release ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract We make use of a very large dataset of non-small cell lung cancer specimens to examine the molecular epidemiology of EGFR mutations, particularly with respect to rare and compound mutations, and to non-adenocarcinoma histological subtypes. We also demonstrate the feasibility of large-scale EGFR mutation screening using the full range of specimens encountered in routine practice. We retrospectively reviewed 18,920 unselected EGFR mutation results from our centre between July 2009 and October 2016, using Qiagen's therascreen EGFR RGQ PCR Kit. Mutation rates were correlated with patient demographics and tumo...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
CONCLUSIONS: - The NGS approach would result in the identification of a significant number of actionable gene alterations, increasing the therapeutic options for patients with advanced NSCLCs. PMID: 29219616 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
The evolution of personalised medicine in lung cancer has dramatically impacted diagnostic pathology. Current challenges centre on the growing demands placed on small tissue samples by molecular diagnostic techniques. In this review, expert recommendations are provided regarding successful identification of anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC). Steps to correctly process and conserve tumour tissue during diagnostic testing are essential to ensure tissue availability. For example, storing extra tissue sections ready for molecular diagnostic steps allows faster testing and preserves ...
Source: Annals of Oncology - Category: Cancer & Oncology Authors: Tags: reviews Source Type: research
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