Effects of Triple-Mutated Hypoxia-Inducible Factor-1 α on Angiogenesis and Cardiac Function Improvement in Rats with Myocardial Infarction

Conclusion: Mutation of Pro402, Pro564 and Asn803 are beneficial for enhancement of the efficacy of HIF-1 α. Ad-HIF–1α-Trip is able to improve angiogenesis and cardiac function, which may be a promising avenue for treatment of ischemic heart disease in the future.Cell Physiol Biochem 2018;50:2329 –2340
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research