Slc4a8 in the Kidney: Expression, Subcellular Localization and Role in Salt Reabsorption

Conclusion: Slc4a8 (NDCBE) is absent in the CCD and is predominantly localized on the basolateral membrane of medullary collecting duct cells. Further, Slc4a8 deletion does not cause significant acid base or electrolyte abnormalities in pathophysiologic states. Additional studies are needed to examine the role of Slc4a8 (NDCBE) in intracellular pH and volume regulation in medullary collecting duct cells.Cell Physiol Biochem 2018;50:1361 –1375
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research