Molecules, Vol. 23, Pages 2669: Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease

Molecules, Vol. 23, Pages 2669: Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease Molecules doi: 10.3390/molecules23102669 Authors: James Doonan David Thomas Michelle H. Wong Hazel J. Ramage Lamyaa Al-Riyami Felicity E. Lumb Kara S. Bell Karen J. Fairlie-Clarke Colin J. Suckling Kathrin S. Michelsen Hui-Rong Jiang Anne Cooke Margaret M. Harnett William Harnett Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein derived from Acanthocheilonema viteae, a filarial nematode parasite of gerbils, which is anti-inflammatory by virtue of covalently-attached phosphorylcholine (PC) moieties. ES-62 has been found to protect against disease in mouse models of rheumatoid arthritis, systemic lupus erythematosus, and airway hyper-responsiveness. Furthermore, novel PC-based synthetic small molecule analogues (SMAs) of ES-62 have recently been demonstrated to show similar anti-inflammatory properties to the parent molecule. In spite of these successes, we now show that ES-62 and its SMAs are unable to provide protection in mouse models of certain autoimmune conditions where other helminth species or their secreted products can prevent disease development, namely type I diabetes, multiple scle...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research

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