TIGAR inclusion pathology is specific for Lewy body diseases.

CONCLUSIONS: TIGAR protein, is present in SN Lewy bodies of both sporadic PD and DLB. The absence of TIGAR protein in the pathological inclusions of MND or MSA suggests disease specificity and further raises the possibility that TIGAR may be involved in PD pathogenesis.
PMID: 30267647 [PubMed - as supplied by publisher]

Source: Brain Research - September 26, 2018 Category: Neurology Authors: Robles López KL, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O, Highley JR Tags: Brain Res Source Type: research