Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder,Depression and Schizophrenia.

CONCLUSION: Difference between bipolar disorder, schizophrenia and depression in PON1 activity and PON1 phenotype might be suggestive of different liability to lipid peroxidation and neurodegeneration between the diagnostic groups. Longitudinal studies may identify long term differences between PON1 Q192R polymorphisms in clinical outcomes and neuropathology. PMID: 30215835 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research

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Did the movie Joker portray mental illness correctly and does it matter? We passionately go over the movie Joker from the lense of people living with mental illness and discuss whether or not there are implications of making a movie like this. Does it help us or hurt us? What if it does both? Listen in to hear Gabe’s freakishly good recollection of scenes from the movie as Jackie struggles to separate entertainment from reality.  Spoiler Alert: You don’t need to see Joker to appreciate this conversation but we do go over the plot and reveal some important scenes from the movie. (Transcript Available Below)...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Antidepressant Antipsychotic Depression Minding the Media Not Crazy Podcast Source Type: blogs
We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q 
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This study determines the relationship between cognition and vascular burden in patients with SMD. Methods: Sixty SMD patients (61% men, mean age: 46) attending a psychosocial rehabilitation centre were included. We evaluated sociodemographic, clinical, laboratory, quality of life and functionality characteristics. And we analysed the association between cognitive performance and vascular burden. Results: SMD diagnoses were: 41.7% schizophrenia, 20.0% bipolar, 5.0% schizoaffective, 21.7% depressive and 11.7% other. Cognitive impairment was present in 55% of the cases. The average vascular burden was 3.2. Patients with cogn...
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
This article suggests that systems biology, emphasizing the epigenetic component of systems biology, could help identify clinically useful biomarkers in neuropsychiatric disorders like SZ, BD, and MDD.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms-Clinician rated scale (IDS-C). ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Abstract BACKGROUND: Bipolar disorder (BD) is a highly heritable mood disorder with complex genetic architecture and poorly understood etiology. Previous transcriptomic BD studies have had inconsistent findings due to issues such as small sample sizes and difficulty in adequately accounting for confounders like medication use. METHODS: We performed a differential expression analysis in a well-characterized BD case-control sample (Nsubjects = 480) by RNA sequencing of whole blood. We further performed co-expression network analysis, functional enrichment, and cell type decomposition, and integrated differentia...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ  = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms—Clinician rated scale (I...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Our findings demonstrate that, while genetic risk factors for depression are largely shared with Neu, there are also non-Neu-related features of depression that may be useful for further patient or phenotypic stratification. PMID: 31576797 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Each year, the first full week in October has been designated as MENTAL ILLNESS AWARENESS WEEK to raise awareness, educate the public, fight stigma and help support children and adults living with a mental health condition. This year, the dates are October 6th through the 9th.Here are some Statistics19.1% of U.S. adults experienced mental illness in 2018 (47.6 million people). This represents 1 in 5 adults.4.6% of U.S. adults experienced serious mental illness in 2018 (11.4 million people). This represents 1 in 25 adults.16.5% of U.S. youth aged 6-17 experienced a mental health disorder in 2016 (7.7 mil...
Source: Dr. Deborah Serani - Category: Psychiatry & Psychology Tags: awareness campaigns mental health Source Type: blogs
 In the first full episode of Not Crazy, we learn a little more about the new co-host, Jackie, and her history with chronic illness and depression. Gabe rants about person-first language and how nitpicking verbiage is distracting from more pressing matters in the lives of those living with mental illness.  Overall, we decide that “crazy” is not a dirty word and there are other, more time-sensitive, things we should be focusing on that can benefit the mental health community.  SUBSCRIBE &REVIEW About The Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Self-Help Stigma Source Type: blogs
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