Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease

Conclusions A significant proportion of HD patients met criteria for subclinical vitamin K deficiency. Of the biomarkers measured, PIVKA-II may be superior given its independence of renal function or dyslipidemia, both of which may confound the other vitamin K biomarkers. Studies in patients with ESKD linking biomarkers of vitamin K status to important patient outcomes, including cardiovascular disease, nutritional status and mortality, are required in order to determine the optimal biomarker for evaluating vitamin K status in this particular population.
Source: Canadian Journal of Kidney Health and Disease - Category: Urology & Nephrology Source Type: research