Risk of ESRD and Mortality in Kidney and Bladder Stone Formers

ConclusionsThe higher risk for ESRD in recurrent symptomatic compared with incident symptomatic kidney stone formers suggests that stone events are associated with kidney injury. The clinical indication for imaging in asymptomatic stone formers, the correct diagnosis in miscoded stone formers, and the cause of a bladder outlet obstruction in bladder stone formers may explain the higher risk for ESRD or death in these groups.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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Authors: Guadagno E, De Rosa G, Nappi O Abstract A national project for the quality assessment of breast immunohistochemistry, involving 155 pathology laboratories distributed all over the Italian territory ( 19 regions), was carried out. The Project lasted one year from December 2014 to December 2015 and it was strongly supported by the Italian Society of Anatomic Pathology (SIAPEC/IAP). Proficiency tests were carried out by the Nordic Immunohistochemical Quality Control (NordiQC) organization. The main aim of the project was to investigate on the general performance of immunohistochemistry (ER, PR and HER2) in th...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
ConclusionIn this nationwide study, multiple sclerosis patients did not have increased cancer incidence or increased cancer-specific mortality. We observed an increased risk of malignant melanoma mainly attributed to increased risk in the first part of our study period.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionConventional MRI, diffusion weighted imaging and contrast enhanced MR images are superior to TVUS in patients with endometrial cancer and ADC values help to differentiate between normal and endometrial cancer which may replace MR contrast enhanced images.
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
Publication date: Available online 14 December 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): Raja Padidela
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
This study and extension phase are registered with ClinicalTrials.gov, number NCT01205152, and EudraCT, number 2009-009369-32.Findings11 participants were recruited between Oct 6, 2008, and Dec 4, 2009. Ten patients completed a 6 month treatment period and entered the extension phase; nine received asfotase alfa for at least 6 years and completed the study, with four being treated for more than 7 years. Skeletal healing was sustained over 7 years of treatment; all evaluable patients had RGI-C scores of at least +2 at year 6 (n=9; median score +2·0 [range 2·0–3·0]) and year 7 (n=7; median score +2...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
This study aimed to measure the effects of duodenal-jejunal exclusion (DJE) on glycometabolism in non-obese type 2 diabetic rats, and to investigate the mechanisms. Goto–Kakizaki(GK) rats and Sprague–Dawley(SD) rats were divided into DJE operation groups and sham operation groups respectively. The glucose relative parameters were measured before and after operation. 8 weeks postoperation, the levels of the key regulators of intestinal gluconeogenesis and the crucial proteins of hepatic insulin signaling were evaluated. Postoperatively, the concentration of blood glucose declined and the insulin sensitivity was ...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: February 2019Source: Biomedicine &Pharmacotherapy, Volume 110Author(s): Tolulope Eniola Omolekulo, Olugbenga Samuel Michael, Lawrence Aderemi OlatunjiAbstractDipeptidyl peptidase-4 (DPP-4) inhibition has been shown to exert beneficial effects against insulin resistance (IR) and type 2 diabetes. Combined oral contraceptive (COC) treatment is associated with impaired glucose and lipid metabolism but the mechanisms are elusive. We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthi...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. An in vivo assay also revealed that miR-542-3p overexpression significantly attenuated tumor growth. Mechanistically, the gene of cyclin-dependent kinase 14 (CDK14) was identified as a novel target of miR-542-3p. CDK14 overexpression reversed the suppressive effects of miR-542-3...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: The study found a high prevalence rate of MetS and substantial undertreatment of the components of MetS in patients with BD in a Dutch outpatient clinic. Follow-up investigation in larger samples is warranted. PMID: 30549480 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
In conclusion, trial recruitment – requiring both geriatric as well as molecular eligibility criteria – proved more difficult than expected. Bearing in mind the very small sample size, upfront cetuximab treatment appeared tolerable and showed promising activity in left-sided tumors in both treatment arms.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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