PDAC-derived cell lines show phenotypic heterogeneity in response to an EMT-stimulus

Objectives Pancreatic ductal adenocarcinoma (PDAC) is the projected second leading cause of cancer related deaths within the next decade and it is characterized by a high rate of metastasis formation. Carcinoma cells which disseminate to distant organs can undergo a process which is called epithelial-to-mesenchymal transition (EMT) to gain invading properties. PDAC cells that undergo EMT express a variety of marker genes, such as EMT transcription factors (e.g. Snail, Slug, Twist 1/2, Zeb1/2) as well as fibroblast markers, such as collagens or Fsp1.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Stefanie B ärthel, Kathleen Schuck, Quentin Müller, Magdalena Zukowska, Nina Schönhuber, Christian Veltkamp, Barbara Seidler, Roland M. Schmid, Dieter Saur Tags: 4. Experimental pancreatitis and cell biology II Source Type: research