You never know the life you save....become an organ donor!

The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are waiting for help.  But they can ’t wait forever. Out of sight, out of mind is how we tend to live each day …if we aren’t experiencing the situation in our own circle of family and friends, we aren’t really affected by it.  But take a moment to think about it ….children who were burned in fires need skin tissue….others were born with heart defects that prevent them from living a full life. When you see these situations, your heart goes out to them. Can you imagine being the parent of a child needing a transplant …the worry, the stress, the fear that your child may die before an organ is available?Fortunately there is something each of us can do to help.  Become an organ donor. While adult sized organs can ’t always be used for a child, many things can such as eye...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news

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Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are dele...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Anna M. D. Watson1,2*, Eleanor A. M. Gould2, Sally A. Penfold2, Gavin W. Lambert2,3, Putra Riza Pratama2, Aozhi Dai1, Stephen P. Gray2, Geoffrey A. Head2† and Karin A. Jandeleit-Dahm1,2† 1Department of Diabetes, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia 2Baker Heart and Diabetes Institute, Melbourne, VIC, Australia 3Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, Swinburne University of Technology, Hawthorn, VIC, Australia Patients with diabetic hypertensive nephropathy have accelerated ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions Lymphatic vessels, like blood vessels, are a highly interactive surface for cells of the immune system, and through the use of chemokines and their receptors can coordinate key interactions. These pathways can control the entry and function of particular immune subsets in a number of pathological conditions. Nonetheless LECs have distinct patterns of chemokine secretion and expression of chemokine receptors that distinguish them from the blood vessel system and mediate distinct roles and responses. The abundance and diversity of the chemokine family point to the likelihood that a plethora of novel chemokine fu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Gene-editing technology has accelerated progress on animal organ transplant to the point where scientists will soon begin the first human trialsScientist Wenning Qin holds up a Petri dish, carefully sloshes around the pink liquid inside, and slides it under a microscope. Some identical tiny slashes come into focus. These cells, she explains, are derived from the ear of a pig. And they may contain the future of animal to human organ transplantation.Researchers in South Korea are expected to transplant pig corneasinto humans within a year. A handful of groups across the US are also working toward pig organ clinical trials in...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Gene editing Science Health Organ donation Society Source Type: news
Gene-editing technology has accelerated progress on animal organ transplant to the point where scientists will soon begin the first human trialsScientist Wenning Qin holds up a Petri dish, carefully sloshes around the pink liquid inside, and slides it under a microscope. Some identical tiny slashes come into focus. These cells, she explains, are derived from the ear of a pig. And they may contain the future of animal to human organ transplantation.Researchers in South Korea are expected to transplant pig corneasinto humans within a year. A handful of groups across the US are also working toward pig organ clinical trials in...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Gene editing Science Health Organ donation Society Source Type: news
We examined whether cognitive impairment influences the likelihood for transplant listing and whether patients with cognitive impairment take longer to be listed. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: We conducted a single-center longitudinal cohort study. Patients presenting for their index kidney transplant evaluation were screened for cognitive impairment using the Montreal Cognitive Assessment. A score
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
By ANISH KOKA MD  The message comes in over the office slack line at 1:05 pm. There are four patients in rooms, one new, 3 patients in the waiting room. Really, not an ideal time to deal with this particular message. “Kathy the home care nurse for Mrs. C called and said her weight yesterday was 185, today it is 194, she has +4 pitting edema, heart rate 120, BP 140/70 standing, 120/64 sitting” I know Mrs. C well. She has severe COPD from smoking for 45 of the last 55 years. Every breath looks like an effort because it is. The worst part of it all is that Mrs. C just returned home from the hospital just days...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Hospitals Medicare Anish Koka hospital readmissions HRRP MedPAC Source Type: blogs
In conclusion, there are many anti-aging strategies in development, some of which have shown considerable promise for slowing down aging or delaying the onset of age-related diseases. From multiple pre-clinical studies, it appears that upregulation of autophagy through autophagy enhancers, elimination of senescent cells using senolytics, transfusion of plasma from young blood, neurogenesis and BDNF enhancement through specific drugs are promising approaches to sustain normal health during aging and also to postpone age-related diseases. However, these approaches will require critical assessment in clinical trials to determ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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