Sociodemographic disparities in the occurrence of medical conditions among adolescent and young adult Hodgkin lymphoma survivors

ConclusionStrategies to improve health care utilization for surveillance and secondary prevention among AYA HL survivors at increased risk of medical conditions may improve outcomes.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research

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In this study, we observed that Iba-1 and P2X4R expression is increased in microglia treated with MCP-1, and blockade with a selective CCR2 antagonist RS-504393 suppressed microglia activation and reduced P2X4R expression in cultured microglia. In response to MCP-1, the expression level of p-Akt was also increased and RS-504393 inhibited the increase. Besides, PI3K inhibitor LY 294002 could attenuate MCP-1-induced P2X4R expression in cultured microglia. MCP-1 was found to be associated with P2X4R expression and mechanical allodynia induced by CIBP in vivo since the expression of MCP-1 was increased in CIBP and RS-504393 al...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
I never miss a check-up, even ‘embarrassing’ ones, and I’m first in line for a flu shot. Every ache and pain has me calling my GP, convinced that it’s cancer, says JO ELVIN.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A combination of Merck&Co's immunotherapy Keytruda and Pfizer Inc's Inlyta helped patients with advanced kidney cancer live longer than those receiving and older Pfizer standalone therapy, according to data from a late-stage study presented on Saturday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The way doctors typically approach kidney cancer treatment could be evolving.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Authors: Kikuchi S, Kubota T, Kuroda S, Nishizaki M, Kagawa S, Kato H, Okada H, Fujiwara T Abstract Endoscopic ultrasound (EUS)-guided transgastric drainage has been performed as a less invasive procedure for pancreatic fistulas and intra-abdominal abscesses occurring after surgery in recent years. However, there are no reports of EUS-guided transgastric drainage of intra-abdominal abscesses following gastrectomy. This case report describes 2 patients who developed an intra-abdominal abscess following gastrectomy and underwent EUS-guided transgastric drainage. Both patients underwent laparoscopy-assisted distal gas...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Publication date: 15 May 2019Source: Sensors and Actuators B: Chemical, Volume 287Author(s): Lutan Zhang, Yuhong Zhang, Lizhen Huang, Yangli Zhang, Ying Li, Shijia Ding, Wei ChengAbstractBRAF V600E mutation is an important drive gene mutation and biomarker for tumor diagnosis, monitoring and target treatment. In order to meet the needs of identifying low abundance BRAF V600E mutation from real clinical specimens, a real time fluorescent biosensing strategy was developed by perfectly integrating dual padlock-gap-ligase chain reaction (DP-gLCR) with hyperbranched rolling circle amplification (HRCA). A pair of padlock probes ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 15 February 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Eman M. Hassan, Ahmed Mohamed, Maria C. DeRosa, William G. Willmore, Yuki Hanaoka, Toshihiko Kiwa, T. OzakiAbstractWe demonstrate high-sensitivity detection of metastatic breast cancer cells using terahertz (THz) chemical microscopy (TCM) with aptamers as ligands. For the aptamers, we use previously developed synthetic single stranded (ss) DNA aptamers mammaglobin B1 (MAMB1) and mammaglobin A2 (MAMA2) that bind to mammaglobin B and mammaglobin A proteins, respectively, which are overexpressed on the surface of MCF7 and MD...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: May 2019Source: Phytochemistry, Volume 161Author(s): Paul A. Weston, Saliya Gurusinghe, Emily Birckhead, Dominik Skoneczny, Jane C. Quinn, Leslie A. WestonAbstractAmaranthus retroflexus L., an introduced invasive weed in southern Australia, has been associated with acute renal failure and/or mortality in a number of livestock species. While its leaves, flowers and stems are generally reported to contain high levels of nitrogen, few studies have fully characterised the chemical composition of A. retroflexus foliage with respect to mammalian toxicity. We performed extensive metabolic profiling of stems, lea...
Source: Phytochemistry - Category: Chemistry Source Type: research
Publication date: Available online 16 February 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Priyanka Khanvilkar, Ramadevi Pulipaka, Kavita Shirsath, Ranjitsinh Devkar, Debjani ChakrabortyAbstractSynthesis, characterization, DNA/BSA binding and cytotoxicity of organometallic binuclear Ru (II) complexes [(p-cym)(Fc-AA)Ru(μ-Im)Ru(Fc-AA)(p-cym)]Cl (C1–C4; where: p-cym = p-cymene MeC6H4Pri, Fc-AA = N-ferrocenyl amino acid conjugates (Fc-tyr1, Fc-phe2, Fc-leu3, Fc-trp4) and Im = Imidazole) have been described. The complexes C1–C4 exhibited strong DNA/BSA binding affinity and cytotoxicity ag...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Grandori's company SEngine, is preparing for a future in which cancer is not going to be treated according to cancer type – like breast or colon – but it will be treated based on its genetic underpinning.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
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