Glycogen synthase kinase 3 β helps heart to pump better in obese patients

Obesity is a growing problem worldwide and is associated with a wide range of comorbidities such as type-2 diabetes (T2D), rheumatoid arthritis, cognitive impairment and dementia, hypertension, stroke and heart failure [1]. The global obesity pandemic affects all age groups. A recent study, based on body mass index (BMI) in over 68 million subjects from 195 countries, suggests that prevalence of metabolic diseases was increased in high BMI subjects globally in the past 20  years [2]. The increased BMI has been shown to be pathogenically related to several diseases including cardiovascular and stroke-related diseases [3].

Source: International Journal of Cardiology - March 23, 2018 Category: Cardiology Authors: Suresh Kumar Verma Source Type: research