Zika brain damage may go undetected in pregnancy

(University of Washington Health Sciences/UW Medicine) Zika virus may cause significant damage to the fetal brain even when the baby's head size is normal, according to a primate study. The damage can be difficult to detect even with sophisticated brain scans. It may also occur from infections during childhood and adolescence. Hard hit are brain regions that generate new brain cells. Fetal brain structures that may be injured include those where neural stem cells play a role in learning and memory.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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CONCLUSION:Although previous (resolved) ZIKV infection and cross-reactivity of the ELISA method with other flaviviruses cannot be ex.cluded, the study found no confirmed cases of acute ZIKV infection. However, given the presence of the vector in Saudi Arabia, the presence of presumptive positive serology and the ongoing risk of ZIKV entry via a regular influx of travelers from endemic areas, we propose that continuous surveillance be conducted for ZIKV as well for other flaviviruses. Larger-scale nationwide studies are strongly recommended to gain a broader view of the potential threat from ZIKV in the country. LIMITA...
Source: Annals of Saudi Medicine - Category: General Medicine Tags: ISSUE 6 Source Type: research
WEDNESDAY, Dec. 5, 2018 -- Ultrasounds and MRIs during pregnancy and after birth can detect most Zika-related brain abnormalities in infants, researchers report. If a woman is infected with the Zika virus during pregnancy, her child can be born with...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Cambridge team develops organoids or mini placentas to advance knowledge of stillbirth and pre-eclampsiaScientists have grown “mini placentas” in a breakthrough that could transform research into the underlying causes of miscarriage, stillbirth and other pregnancy disorders.The tiny organoids mimic the placenta in the early stages of the first trimester and will be used to understand how the tissue develops in healthy pregnancies, and what goes wrong when it fails.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Pregnancy Reproduction Immunology Biochemistry and molecular biology Zika virus Science University of Cambridge UK news Source Type: news
by Anna S. Heffron, Emma L. Mohr, David Baker, Amelia K. Haj, Connor R. Buechler, Adam Bailey, Dawn M. Dudley, Christina M. Newman, Mariel S. Mohns, Michelle Koenig, Meghan E. Breitbach, Mustafa Rasheed, Laurel M. Stewart, Jens Eickhoff, Richard S. Pinapati, Erica Beckman, Hanying Li, Jigar Patel, John C. Tan, David H. O ’Connor The specificity of the antibody response against Zika virus (ZIKV) is not well-characterized. This is due, in part, to the antigenic similarity between ZIKV and closely related dengue virus (DENV) serotypes. Since these and other similar viruses co-circulate, are spread by the same mosquito ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
(Children's National Health System) Ultrasound imaging performed during pregnancy and after childbirth revealed most Zika-related brain abnormalities experienced by infants exposed to the Zika virus during pregnancy, according to a prospective cohort study published online Nov. 26, 2018, in JAMA Pediatrics.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Although Zika has faded from the media headlines, it remains an important clinical and public health risk for many women and their families. Zika virus infection during pregnancy can cause serious defects of the brain and eye in the offspring, and it has been linked to other neurodevelopmental disabilities, such as seizures, joint contractures, swallowing difficulties, vision impairment, and hearing loss. Women who are pregnant, attempting conception, or at risk for unintended pregnancy may be at risk for the devastating consequences of congenital Zika virus infection if they or their partners live in or travel to affected...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
To describe the role of amniocentesis in diagnosing prenatal Zika virus infection in pregnant women with suspected infection by symptoms and/or abnormal fetal ultrasound findings.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
The Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which was recently linked to microcephaly and other central nervous system anomalies following infection in pregnancy. Evidence is accumulating that some infants exposed to ZIKV in utero that lack structural anomalies at birth may have subtle defects that are challenging to detect prenatally. We hypothesized that aberrant fetal growth, defined by a disproportionately small head or abdomen with respect to the femur, would identify fetuses with ZIKV-associated fetal injuries detected postnatally.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
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