Understanding the molecular mechanisms underpinning G ×E interactions in psychiatric disorders: the FKBP5 model

Epidemiologic and genetic studies suggest common environmental and genetic risk factors for a number of psychiatric disorders, including depression, bipolar disorder and schizophrenia. Genetic and environmental factors, especially adverse life events, not only have main effects on disease development but may also interact to shape risk and resilience. Such gene × adversity interactions have been described for FK binding protein 5 (FKBP5), an endogenous regulator of the stress-neuroendocrine system, conferring risk for a number of psychiatric disorders.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research