Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.

CONCLUSION: DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. PMID: 29375204 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29375204?dopt=Abstract

Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M Tags: World J Gastroenterol Source Type: research