Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion

This study provides functional evidence of a novel mechanism via increased 27OH synthesis during luteolysis, which subsequently represses progesterone secretion. Increased 27OH may also facilitate the progression of luteolysis in domestic animal species.STUDY FUNDING AND COMPETING INTEREST(S)The authors have nothing to disclose. Support was provided by the Eunice Kennedy Shriver National Institute of Child Health& Human Development (NICHD) of the National Institutes of Health (NIH), award number R00HD067678 to R.L.B.
Source: Molecular Human Reproduction - Category: Molecular Biology Source Type: research